Kumar Suresh, Sharma Anupama
University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160 014, India.
J Herb Pharmacother. 2005;5(4):13-21.
Turnera aphrodisiaca Ward (Turneraceae) has been used traditionally for treatment of anxiety neurosis and as an aphrodisiac. Yet, the plant has never been subjected to systematic biological investigation. In the present investigation, petroleum ether (60-80 degrees C), chloroform, methanol, and water extracts of T. aphrodisiaca aerial parts were evaluated for anti-anxiety activity in mice using elevated plus-maze apparatus. Among all the extracts, only methanol exhibited significant anti-anxiety activity at a dose of 25 mg/kg with respect to control as well as standard (diazepam, 2 mg/kg). The bioactive methanol extract was shaken with petroleum ether, chloroform, and n-butyl alcohol, and all the shakings as well as the remaining methanol extract (RME) were further evaluated for anxiolytic activity. Butanol fraction and RME were found to exhibit anxiolytic activity in mice at the dose of 10 mg/kg and 75 mg/kg, respectively.
特纳草（Turnera aphrodisiaca Ward，金虎尾科）传统上用于治疗焦虑症和作为壮阳药。然而，该植物从未接受过系统的生物学研究。在本研究中，使用高架十字迷宫装置评估了特纳草地上部分的石油醚（60 - 80℃）、氯仿、甲醇和水提取物对小鼠的抗焦虑活性。在所有提取物中，仅甲醇在剂量为25 mg/kg时相对于对照以及标准品（地西泮，2 mg/kg）表现出显著的抗焦虑活性。将具有生物活性的甲醇提取物与石油醚、氯仿和正丁醇振荡混合，对所有振荡后的提取物以及剩余的甲醇提取物（RME）进一步评估其抗焦虑活性。发现正丁醇馏分和RME在小鼠中的剂量分别为10 mg/kg和75 mg/kg时表现出抗焦虑活性。
