Lodi R, Pierangeli G, Tonon C, Cevoli S, Testa C, Bivona G, Magnifico F, Cortelli P, Montagna P, Barbiroli B
Dipartimento di Medicina Clinica e Biotecnologia Applicata, Policlinico S. Orsola-Malpighi, Università di Bologna, Italy.
Neurology. 2006 Apr 25;66(8):1264-6. doi: 10.1212/01.wnl.0000208442.07548.71.
The authors used 1H-MRS to investigate hypothalamic metabolism in 26 patients with cluster headache (CH) and 12 healthy subjects. Hypothalamic N-acetylaspartate/creatine was reduced in patients with CH vs controls (p < 0.01). Dividing the patients into episodic CH outside- and in-cluster periods and chronic CH, the hypothalamic N-acetylaspartate/creatine in all three subgroups of patients was reduced. The reduction of the neuronal marker N-acetylaspartate is consistent with hypothalamic neuronal dysfunction in patients with CH.
作者使用1H-磁共振波谱（1H-MRS）研究了26例丛集性头痛（CH）患者和12名健康受试者的下丘脑代谢情况。与对照组相比，CH患者下丘脑的N-乙酰天门冬氨酸/肌酸降低（p<0.01）。将患者分为发作性CH的发作间期和发作期以及慢性CH，所有三个患者亚组的下丘脑N-乙酰天门冬氨酸/肌酸均降低。神经元标志物N-乙酰天门冬氨酸的降低与CH患者的下丘脑神经元功能障碍一致。
