细胞间黏附分子-1（ICAM-1）E469K基因多态性是自发性颈内动脉夹层的一个危险因素。
The ICAM-1 E469K gene polymorphism is a risk factor for spontaneous cervical artery dissection.
作者信息
Longoni M, Grond-Ginsbach C, Grau A J, Genius J, Debette S, Schwaninger M, Ferrarese C, Lichy C
机构信息
Department of Neurology, University of Milano-Bicocca, Monza, Monza, Italy.
出版信息
Neurology. 2006 Apr 25;66(8):1273-5. doi: 10.1212/01.wnl.0000208411.01172.0b.
In a primary study on proinflammatory genetic profiles in stroke, the authors found the E469K polymorphism of the intercellular adhesion molecule 1 (ICAM-1) highly represented in the subgroup with spontaneous cervical artery dissection (sCAD). They further investigated the same genetic variant in a second group of 65 patients with sCAD. An association between sCAD and EE genotype was confirmed (odds ratio 3.16; p < 0.01), indicating that a proinflammatory predisposition is a risk factor for sCAD.
在一项关于中风促炎基因谱的初步研究中，作者发现细胞间黏附分子1（ICAM-1）的E469K多态性在自发性颈动脉夹层（sCAD）亚组中高度富集。他们在另一组65例sCAD患者中进一步研究了相同的基因变异。sCAD与EE基因型之间的关联得到证实（优势比3.16；p<0.01），表明促炎易感性是sCAD的一个危险因素。
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