来自海湾群岛民族医学的剂量依赖性治疗性抗感染药物。
Dose-dependent therapeutic antiinfectives from ethnomedicines of bay islands.
作者信息
Chattopadhyay D, Arunachalam G, Mandal A B, Bhattacharya S K
机构信息
ICMR Virus Unit, ID & BG Hospital, Kolkata, India.
出版信息
Chemotherapy. 2006;52(3):151-7. doi: 10.1159/000092859. Epub 2006 Apr 21.
BACKGROUND
The methanol extract of Ophirrhiza nicobarica, Alstonia macrophylla and Mallotus peltatus, ethnomedicines of Little Andaman, were investigated for antiinfective, antiinflammatory and antioxidant activities.
METHODS
Toxicity was determined in cells and in an animal model. Antiviral, antibacterial and antifungal activity was determined by plaque reduction, disc diffusion and agar dilution methods. The antiinflammatory and antioxidant activities were also studied.
RESULTS
O. nicobarica at 300 microg ml(-1) showed anti-HSV activity while M. peltatus and A. macrophylla showed antibacterial activity at 64-1,000 microg ml(-1). Both extracts showed significant dose-dependent antiinflammatory and antioxidant activity at nontoxic concentrations.
CONCLUSION
The alkaloid, flavonoid and beta-sitosterol isolated from bioactive parts had a dose-dependent therapeutic efficacy, justifying their use. Further study is required to know the mechanism of action.
背景
对安达曼小岛上的三种民间药用植物——尼科巴蛇根草、大叶鸡骨常山和盾叶野桐的甲醇提取物进行了抗感染、抗炎和抗氧化活性研究。
方法
在细胞和动物模型中测定毒性。采用噬斑减少法、纸片扩散法和琼脂稀释法测定抗病毒、抗菌和抗真菌活性。同时研究了抗炎和抗氧化活性。
结果
尼科巴蛇根草在300微克/毫升时显示出抗单纯疱疹病毒活性，而盾叶野桐和大叶鸡骨常山在64 - 1000微克/毫升时显示出抗菌活性。两种提取物在无毒浓度下均显示出显著的剂量依赖性抗炎和抗氧化活性。
结论
从生物活性部位分离得到的生物碱、黄酮类化合物和β-谷甾醇具有剂量依赖性治疗效果，证明了它们的药用价值。需要进一步研究以了解其作用机制。
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