Department of Research, Canadian College of Naturopathic Medicine, Toronto, Ontario, Canada.
J Evid Based Integr Med. 2021 Jan-Dec;26:2515690X20978394. doi: 10.1177/2515690X20978394.
Herpes simplex viruses, HSV-1 and HSV-2, are highly contagious and cause lifelong, latent infections with recurrent outbreaks of oral and/or genital lesions. No cure exists for HSV-1 or HSV-2 infections, but antiviral medications are commonly used to prevent and treat outbreaks. Resistance to antivirals has begun to emerge, placing an importance on finding new and effective therapies for prophylaxis and treatment of HSV outbreaks. Botanicals may be effective HSV therapies as the constituents they contain act through a variety of mechanisms, potentially making the development of antiviral resistance more challenging. A wide variety of plants from different regions in the world have been studied for antiviral activity against HSV-1 and/or HSV-2 and showed efficacy of varying degrees. The purpose of this review is to summarize research conducted on whole plant extracts against HSV-1 and/or HSV-2 in vitro and in vivo. The majority of the research reviewed was conducted in vitro using animal cell lines, and some studies used an animal model design. Also summarized are a limited number of human trials conducted using botanical therapies on HSV lesions.
单纯疱疹病毒 1 型（HSV-1）和 2 型（HSV-2）具有高度传染性，可导致终生潜伏感染，并反复发作口腔和/或生殖器病变。目前尚无治愈 HSV-1 或 HSV-2 感染的方法，但抗病毒药物常用于预防和治疗发作。对抗病毒药物的耐药性已开始出现，因此寻找新的有效的预防和治疗 HSV 发作的疗法非常重要。植物药可能是有效的 HSV 治疗方法，因为它们所含的成分通过多种机制发挥作用，这可能使抗病毒耐药性的发展更加具有挑战性。来自世界各地不同地区的多种植物已被研究用于对抗 HSV-1 和/或 HSV-2 的抗病毒活性，并显示出不同程度的疗效。本综述的目的是总结针对 HSV-1 和/或 HSV-2 的全植物提取物的体外和体内研究。综述的大部分研究是在使用动物细胞系进行的体外进行的，一些研究使用了动物模型设计。还总结了少数使用植物疗法治疗 HSV 病变的人体临床试验。
