Lee Young Rae, Lee Kyu-Beck
Department of Radiology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Jong-no ku, Seoul, Korea.
Nephron Clin Pract. 2006;103(4):c173-80. doi: 10.1159/000092915. Epub 2006 Apr 24.
The purpose of this study was to determine if renal volumetric indices can be accurately measured using MRI, and if these volumetric indices are associated with hypertension and renal function in patients with autosomal-dominant polycystic kidney disease (ADPKD).
For testing the accuracy of the MRI-based volume measurements that we proposed for clinical trial, we designed phantoms to simulate cysts within the kidney. Fifty-six patients with ADPKD were included in this study, and their respiratory compensated T2-weighted fast spin-echo images were acquired. The total kidney volume (Vt), cyst volume (Vc), and noncystic parenchymal volume (Vp) were measured and the percent cyst volume (Pc) was calculated. These volumetric indices were compared with the disease progression in the ADPKD patients.
The MRI measures of the phantoms were accurate. The Vt, Vc and Pc were significantly greater in the hypertensive group (n = 35) than in the normotensive group (n = 21) (p < 0.01). The Vt, Vc and Pc were significantly greater in the renal failure group (n = 23) than in the normal renal function group (n = 33) (p < 0.01). The Vt, Vc, and Pc were inversely correlated with the creatinine clearance.
MRI is a reliable method to measure renal volumetric indices. The MRI-based volume measurements can be employed as useful markers for the progression of disease in ADPKD patients.
本研究的目的是确定磁共振成像（MRI）能否准确测量肾脏体积指数，以及这些体积指数是否与常染色体显性多囊肾病（ADPKD）患者的高血压和肾功能相关。
为了测试我们在临床试验中提出的基于MRI的体积测量方法的准确性，我们设计了模拟肾脏囊肿的模型。本研究纳入了56例ADPKD患者，并采集了他们的呼吸补偿T2加权快速自旋回波图像。测量了总肾体积（Vt）、囊肿体积（Vc）和非囊肿实质体积（Vp），并计算了囊肿体积百分比（Pc）。将这些体积指数与ADPKD患者的疾病进展情况进行了比较。
模型的MRI测量结果准确。高血压组（n = 35）的Vt、Vc和Pc显著高于血压正常组（n = 21）（p < 0.01）。肾衰竭组（n = 23）的Vt、Vc和Pc显著高于肾功能正常组（n = 33）（p < 0.01）。Vt、Vc和Pc与肌酐清除率呈负相关。
MRI是测量肾脏体积指数的可靠方法。基于MRI的体积测量可作为ADPKD患者疾病进展的有用标志物。
