Bae Kyongtae T, Zhu Fang, Chapman Arlene B, Torres Vicente E, Grantham Jared J, Guay-Woodford Lisa M, Baumgarten Deborah A, King Bernard F, Wetzel Louis H, Kenney Philip J, Brummer Marijn E, Bennett William M, Klahr Saulo, Meyers Catherine M, Zhang Xiaoling, Thompson Paul A, Miller J Philip
Department of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Clin J Am Soc Nephrol. 2006 Jan;1(1):64-9. doi: 10.2215/CJN.00080605. Epub 2005 Oct 26.
The objective of this study was to investigate the prevalence of hepatic cysts by age and gender in patients with early autosomal-dominant polycystic kidney disease (ADPKD) and to determine whether hepatic cyst volume is related to renal and renal cyst volumes by using magnetic resonance imaging (MRI). A total of 230 patients with ADPKD (94 men and 136 women) who were aged 15 to 46 yr and had relatively preserved renal function were studied. MRI images of the kidney and liver were obtained to measure renal, renal cyst, and hepatic cyst volumes. These volume measurements and hepatic cyst prevalence were compared in all patients and in subgroups on the basis of gender and age (15 to 24, 25 to 34, and 35 to 46 yr). The overall prevalence of hepatic cysts was 83%; the prevalence was 58, 85, and 94% in the sequential age groups and 85% in women and 79% in men. The prevalence was related directly to renal volume (chi2 = 4.30, P = 0.04) and to renal cyst volume (chi2 = 5.59, P = 0.02). The total hepatic cyst volume was significantly greater in women than in men (a logarithmic transformation mean of 5.27 versus 1.94 ml; P = 0.003). The average hepatic cyst volume was 0.25, 5.75, and 22.78 ml in sequential age groups. Hepatic cysts are evident in 94% of patients who are older than 35 yr and in 55% of individuals who are younger than 25 yr. Hepatic cysts are more prevalent and larger in total cyst volume in women than in men. Hepatic cyst prevalence and aggregate total hepatic cyst volume increased with age.
本研究的目的是通过磁共振成像（MRI），调查常染色体显性遗传性多囊肾病（ADPKD）早期患者肝囊肿按年龄和性别的患病率，并确定肝囊肿体积是否与肾和肾囊肿体积相关。共研究了230例年龄在15至46岁、肾功能相对保留的ADPKD患者（94例男性和136例女性）。获取肾脏和肝脏的MRI图像以测量肾、肾囊肿和肝囊肿体积。在所有患者以及按性别和年龄（15至24岁、25至34岁和35至46岁）划分的亚组中比较这些体积测量值和肝囊肿患病率。肝囊肿的总体患病率为83%；在连续年龄组中的患病率分别为58%、85%和94%，女性患病率为85%，男性患病率为79%。患病率与肾体积直接相关（χ² = 4.30，P = 0.04），与肾囊肿体积也直接相关（χ² = 5.59，P = 0.02）。女性的肝囊肿总体积显著大于男性（对数转换平均值分别为5.27 ml和1.94 ml；P = 0.003）。在连续年龄组中，平均肝囊肿体积分别为0.25 ml、5.75 ml和22.78 ml。94%年龄大于35岁的患者和55%年龄小于25岁的个体存在肝囊肿。女性肝囊肿的患病率更高，且囊肿总体积更大。肝囊肿患病率和肝囊肿总体积随年龄增加而升高。
