Ferguson S J, Broggini N, Wieland M, de Wild M, Rupp F, Geis-Gerstorfer J, Cochran D L, Buser D
MEM Research Center for Orthopaedic Surgery, Institute for Surgical Technology and Biomechanics, University of Berne, Berne, Switzerland.
J Biomed Mater Res A. 2006 Aug;78(2):291-7. doi: 10.1002/jbm.a.30678.
The functional capacity of osseointegrated dental implants to bear load is largely dependent on the quality of the interface between the bone and implant. Sandblasted and acid-etched (SLA) surfaces have been previously shown to enhance bone apposition. In this study, the SLA has been compared with a chemically modified SLA (modSLA) surface. The increased wettability of the modSLA surface in a protein solution was verified by dynamic contact angle analysis. Using a well-established animal model with a split-mouth experimental design, implant removal torque testing was performed to determine the biomechanical properties of the bone-implant interface. All implants had an identical cylindrical shape with a standard thread configuration. Removal torque testing was performed after 2, 4, and 8 weeks of bone healing (n = 9 animals per healing period, three implants per surface type per animal) to evaluate the interfacial shear strength of each surface type. Results showed that the modSLA surface was more effective in enhancing the interfacial shear strength of implants in comparison with the conventional SLA surface during early stages of bone healing. Removal torque values of the modSLA-surfaced implants were 8-21% higher than those of the SLA implants (p = 0.003). The mean removal torque values for the modSLA implants were 1.485 N m at 2 weeks, 1.709 N m at 4 weeks, and 1.345 N m at 8 weeks; and correspondingly, 1.231 N m, 1.585 N m, and 1.143 N m for the SLA implants. The bone-implant interfacial stiffness calculated from the torque-rotation curve was on average 9-14% higher for the modSLA implants when compared with the SLA implants (p = 0.038). It can be concluded that the modSLA surface achieves a better bone anchorage during early stages of bone healing than the SLA surface; chemical modification of the standard SLA surface likely enhances bone apposition and this has a beneficial effect on the interfacial shear strength.
骨结合牙种植体承担负荷的功能能力在很大程度上取决于骨与种植体之间界面的质量。先前已表明，喷砂和酸蚀（SLA）表面可增强骨附着。在本研究中，将SLA与化学改性的SLA（modSLA）表面进行了比较。通过动态接触角分析验证了modSLA表面在蛋白质溶液中增加的润湿性。使用具有分口实验设计的成熟动物模型，进行种植体取出扭矩测试以确定骨-种植体界面的生物力学性能。所有种植体均具有相同的圆柱形形状和标准螺纹结构。在骨愈合2、4和8周后进行取出扭矩测试（每个愈合期n = 9只动物，每只动物每种表面类型三个种植体），以评估每种表面类型的界面剪切强度。结果表明，在骨愈合早期，与传统SLA表面相比，modSLA表面在增强种植体的界面剪切强度方面更有效。modSLA表面种植体的取出扭矩值比SLA种植体高8-21%（p = 0.003）。modSLA种植体的平均取出扭矩值在2周时为1.485 N·m，4周时为1.709 N·m，8周时为1.345 N·m；相应地，SLA种植体分别为1.231 N·m、1.585 N·m和1.143 N·m。与SLA种植体相比，从扭矩-旋转曲线计算得出的骨-种植体界面刚度，modSLA种植体平均高9-14%（p = 0.038）。可以得出结论，在骨愈合早期，modSLA表面比SLA表面能实现更好的骨锚固；标准SLA表面的化学改性可能增强骨附着，这对界面剪切强度有有益影响。
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