Wikstrand Margareta Hök, Strömland Kerstin, Flodin Sara, Bergh Christina, Wennerholm Ulla-Britt, Hellström Ann
Department of Ophthalmology, Sahlgrenska University Hospital, Gothenburg, Sweden.
Acta Ophthalmol Scand. 2006 Apr;84(2):177-81. doi: 10.1111/j.1600-0420.2005.00568.x.
To investigate visual function and ocular morphology in children born after intracytoplasmic sperm injection (ICSI) and compare them with visual function and ocular morphology in matched children born after spontaneous conception.
A total of 137 children born after ICSI and 159 control children were examined at the age of 5 years in a blinded study. The two groups were matched for age, gender and maternal age. The children underwent a detailed ophthalmological investigation by an ophthalmologist and an orthoptist.
A total of 90.4% of the ICSI children had a visual acuity (VA) in the better eye of >or= 0.8, compared with 93.7% of the controls (NS). No significant differences were found between ICSI children and controls with regard to hyperopia, myopia, astigmatism, heterotropia, stereoscopic vision and convergence. One child with Goldenhar syndrome and one with Marcus Gunn syndrome were observed in the ICSI group. One child in the ICSI group was treated for retinopathy of prematurity.
In this limited study group, no significant differences in visual function and/or ocular morphology were found between children born after ICSI and matched control children at the age of 5 years.
研究经卵胞浆内单精子注射（ICSI）出生的儿童的视觉功能和眼部形态，并将其与自然受孕出生的匹配儿童的视觉功能和眼部形态进行比较。
在一项盲法研究中，对137名经ICSI出生的儿童和159名对照儿童在5岁时进行了检查。两组在年龄、性别和母亲年龄方面进行了匹配。这些儿童由一名眼科医生和一名斜视弱视治疗师进行了详细的眼科检查。
ICSI组中，90.4%的儿童较好眼的视力（VA）≥0.8，而对照组为93.7%（无显著差异）。在远视、近视、散光、斜视、立体视觉和集合方面，ICSI组儿童与对照组之间未发现显著差异。ICSI组中观察到一名患有Goldenhar综合征的儿童和一名患有Marcus Gunn综合征的儿童。ICSI组中有一名儿童接受了早产儿视网膜病变的治疗。
在这个有限的研究组中，经ICSI出生的儿童与5岁时匹配的对照儿童在视觉功能和/或眼部形态方面未发现显著差异。
