Perkins Anthony V
Heart Foundation Research Centre, School of Medical Science, Griffith University Gold Coast Campus, Southport, Queensland, Australia.
Aust N Z J Obstet Gynaecol. 2006 Apr;46(2):77-83. doi: 10.1111/j.1479-828X.2006.00532.x.
Oxidative stress has been implicated in a wide variety of diseases and degenerative states including cancer, rheumatoid arthritis, cardiovascular disease and ageing. There is now considerable evidence to suggest that pregnancy leads to the generation of an increased oxidative burden, but whether this overwhelms the anti-oxidant capacity within the placenta and/or the peripheral circulation remains a point of conjecture. There is little doubt that oxidative stress is a significant contributor in the pathogenesis of preeclampsia. The use of exogenous anti-oxidants such as vitamins C and E in the prevention of preeclampsia is the subject of several large clinical trials currently being conducted in many countries around the world. The results of these studies are eagerly awaited, but what of the endogenous anti-oxidant systems that have evolved to combat the oxidative burden associated with living in an aerobic environment? This review will focus on several important anti-oxidant enzyme systems, their role in pregnancy and the evidence to suggest that endogenous anti-oxidants are important in the development of complications of pregnancy such as preeclampsia.
氧化应激与多种疾病和退行性状态有关，包括癌症、类风湿性关节炎、心血管疾病和衰老。现在有大量证据表明，怀孕会导致氧化负担增加，但这种负担是否会超过胎盘和/或外周循环中的抗氧化能力仍是一个推测点。毫无疑问，氧化应激是先兆子痫发病机制中的一个重要因素。在许多国家目前正在进行的几项大型临床试验的主题是使用外源性抗氧化剂，如维生素C和E来预防先兆子痫。人们热切期待这些研究的结果，但是那些为应对与生活在有氧环境相关的氧化负担而进化出的内源性抗氧化系统又如何呢？这篇综述将聚焦于几种重要的抗氧化酶系统、它们在孕期的作用以及表明内源性抗氧化剂在诸如先兆子痫等妊娠并发症发展中很重要的证据。
