Yilmaz Saynur, Ozgu-Erdinc A Seval, Demirtas Canan, Ozturk Gulfer, Erkaya Salim, Uygur Dilek
Redox Rep. 2015 May;20(3):97-102. doi: 10.1179/1351000214Y.0000000110. Epub 2014 Oct 18.
The etiology and pathogenesis of hyperemesis gravidarum (HG) is still undetermined and has been suggested to involve oxidative stress. We aimed to evaluate the status of oxidative stress in HG by measuring the levels of total oxidant status (TOS), total antioxidant status (TAS), and by calculating the oxidative stress index (OSI).
In a case-control trial, fasting morning blood samples of patients with HG (n = 41) and healthy pregnant women (n = 39) were collected for analysis of serum TOS and TAS values as well as for calculation of OSI according to the formula: OSI = TOS / TAS × 100.
Serum TOS and TAS levels were similar in both groups. However, serum TAS levels were lower among HG patients compared to controls, which resulted in an increase in OSI (P = 0.025).
The present study supports the role of systemic oxidative stress, reflected by an imbalance between the TOS and TAS, in patients with HG. Our findings distinguish the mechanism underlying oxidative stress to result from reduction of antioxidants rather than an increase in oxidants.
妊娠剧吐（HG）的病因和发病机制仍未明确，有研究提示其与氧化应激有关。我们旨在通过检测总氧化状态（TOS）、总抗氧化状态（TAS）水平并计算氧化应激指数（OSI）来评估HG患者的氧化应激状态。
在一项病例对照试验中，采集HG患者（n = 41）和健康孕妇（n = 39）空腹晨尿样本，用于分析血清TOS和TAS值，并根据公式OSI = TOS / TAS × 100计算OSI。
两组血清TOS和TAS水平相似。然而，与对照组相比，HG患者血清TAS水平较低，导致OSI升高（P = 0.025）。
本研究支持全身氧化应激在HG患者中的作用，这表现为TOS和TAS之间的失衡。我们的研究结果表明，氧化应激的潜在机制是抗氧化剂减少而非氧化剂增加。
