有时是中间体。完成工作！
Sometimes intermediates. Do the job!
作者信息
Hilgenfeld Rolf, Pumpor Ksenia
机构信息
Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany.
出版信息
Chem Biol. 2006 Mar;13(3):235-6. doi: 10.1016/j.chembiol.2006.03.002.
Abstract
The SARS coronavirus main proteinase is a prime target for antiviral therapy. In this issue of Chemistry & Biology, Wu et al. describe potent inhibition of the enzyme by benzotriazole esters, which were originally obtained as intermediates in the synthesis of lopinavir derivatives .
摘要
严重急性呼吸综合征冠状病毒主要蛋白酶是抗病毒治疗的主要靶点。在本期《化学生物学》中，吴等人描述了苯并三唑酯对该酶的有效抑制作用，这些苯并三唑酯最初是作为洛匹那韦衍生物合成中的中间体获得的。
Zotero 插件