Rigopoulou Eirini I, Georgiadou Sarah P, Barbanis Sotiris, Dalekos Georgios N
Department of Internal Medicine, Academic Liver UnitUniversity of Thessaly, Medical School, Larissa, Greece.
Scand J Gastroenterol. 2006 May;41(5):573-6. doi: 10.1080/00365520500319633.
In view of the possible implication of various environmental factors in the pathogenesis of primary biliary cirrhosis (PBC), the role of appendectomy in patients with PBC and other chronic liver diseases from Central Greece was investigated.
The medical files of 68 patients with PBC and gender- and age-matched controls with chronic hepatitis C virus (HCV) infection (n=65) and chronic hepatitis B virus (HBV) infection (n=67) were reviewed for the history and time of appendectomy.
Nineteen of 68 (27.9%) PBC patients, 32 of 65 (49.2%) patients with chronic HCV infection and 22 of 67 (32.8%) patients with chronic HBV infection had a history of appendectomy. There was a significant higher frequency of appendectomy in patients with chronic hepatitis C (p = 0.012, chi(2) test) compared to patients with PBC. There were no significant differences in the clinical and histological characteristics of PBC patients with or without a history of appendectomy.
In this case-control study we were unable to provide evidence of an association between primary biliary cirrhosis and the occurrence of appendectomy.
鉴于多种环境因素可能在原发性胆汁性肝硬化（PBC）的发病机制中起作用，我们对希腊中部PBC患者及其他慢性肝病患者行阑尾切除术的作用进行了研究。
回顾了68例PBC患者以及年龄和性别匹配的慢性丙型肝炎病毒（HCV）感染对照组（n = 65）和慢性乙型肝炎病毒（HBV）感染对照组（n = 67）的医疗档案，以了解阑尾切除术的病史和时间。
68例PBC患者中有19例（27.9%）、65例慢性HCV感染患者中有32例（49.2%）、67例慢性HBV感染患者中有22例（32.8%）有阑尾切除病史。与PBC患者相比，慢性丙型肝炎患者阑尾切除术的发生率显著更高（p = 0.012，卡方检验）。有或无阑尾切除病史的PBC患者在临床和组织学特征上无显著差异。
在这项病例对照研究中，我们未能提供原发性胆汁性肝硬化与阑尾切除术之间存在关联的证据。
