Wilson Lorri B, Quinn Graham E, Ying Gui-shuang, Francis Ellie L, Schmid Gregor, Lam An, Orlow Josh, Stone Richard A
Division of Pediatric Ophthalmology, The Children's Hospital of Philadelphia, PA 19104, USA.
Invest Ophthalmol Vis Sci. 2006 May;47(5):1778-84. doi: 10.1167/iovs.05-0869.
To determine in human eyes whether diurnal fluctuations in axial length are related to fluctuations in intraocular pressure (IOP) by studying these fluctuations in both eyes of individual subjects and by assessing the regularity of both rhythms on two separate study days.
Ten subjects, ages 18 to 24 years, underwent serial axial length and IOP measurements using highly precise, noncontact partial coherence interferometry and Goldmann applanation tonometry, respectively. Both eyes were measured at six 3-hour intervals during each of two study days, and significant fluctuations were modeled by sine curves.
Of the 40 data sets, 29 had significant axial length high-low differences and 32 had significant IOP high-low differences (ANOVA, P < 0.05 for each). The magnitude of the significant high-low differences were 38 +/- 22 microm for axial length and 6.0 +/- 1.9 mm Hg for IOP (mean +/- SD). Neither axial length nor IOP fluctuations necessarily occurred bilaterally on the same day, and neither rhythm was regularly observed on two separate days in individual eyes. In eyes in which both parameters fluctuated on the same day, there were no correlations in the amplitude, period or phase of the two rhythms.
Both axial length and IOP fluctuate during the day much of the time in most subjects. However, diurnal IOP fluctuations do not appear to cause diurnal axial length fluctuations.
通过研究个体受试者双眼的这些波动情况，并在两个不同的研究日评估两种节律的规律性，来确定人眼的眼轴长度昼夜波动是否与眼压（IOP）波动有关。
10名年龄在18至24岁之间的受试者分别使用高精度非接触式部分相干干涉测量法和Goldmann压平眼压计进行了连续的眼轴长度和眼压测量。在两个研究日的每一天中，每隔3小时对双眼进行一次测量，并用正弦曲线对显著波动进行建模。
在40个数据集中，29个有显著的眼轴长度高低差异，32个有显著的眼压高低差异（方差分析，每项P<0.05）。显著高低差异的幅度，眼轴长度为38±22微米，眼压为6.0±1.9毫米汞柱（平均值±标准差）。眼轴长度和眼压波动不一定在同一天双侧发生，而且在个体眼睛的两个不同日子里也没有规律地观察到任何一种节律。在同一天两个参数都波动的眼睛中，两种节律的幅度、周期或相位均无相关性。
在大多数受试者中，眼轴长度和眼压在一天中的大部分时间里都会波动。然而，眼压的昼夜波动似乎不会导致眼轴长度的昼夜波动。
