Alanko J, Riutta A, Vapaatalo H, Mucha I
Department of Biomedical Sciences, University of Tampere, Finland.
Prostaglandins. 1991 Sep;42(3):279-87. doi: 10.1016/0090-6980(91)90116-w.
Catecholamines (adrenaline, dopamine, isoprenaline, noradrenaline) and caffeic acid (catecholic compound without adrenergic receptor activity) decreased leukotriene (LT)B4 synthesis in A23187-stimulated human whole blood. Salbutamol, a non-catecholic beta 2-adrenergic agonist, did not influence LTB4 synthesis. Catecholamines stimulated thromboxane (TX)B2 synthesis with a concomitant inhibition of LTB4 synthesis; caffeic acid and salbutamol did not stimulate TXB2 synthesis. These results, obtained in A23187-stimulated whole blood, which also takes into account the complex interaction between different cell types, are similar to our previous results with polymorphonuclear leukocytes. Catecholamines show an opposite effect on lipoxygenase and cyclooxygenase pathways, which may give rise to a marked change in LT/TX ratio in physiological or pathological conditions where sufficient concentrations of catecholamines are present.
儿茶酚胺（肾上腺素、多巴胺、异丙肾上腺素、去甲肾上腺素）和咖啡酸（无肾上腺素能受体活性的儿茶酚类化合物）可降低A23187刺激的人全血中白三烯（LT）B4的合成。非儿茶酚类β2肾上腺素能激动剂沙丁胺醇对LTB4的合成无影响。儿茶酚胺刺激血栓素（TX）B2的合成，同时抑制LTB4的合成；咖啡酸和沙丁胺醇不刺激TXB2的合成。在A23187刺激的全血中获得的这些结果，同时也考虑到了不同细胞类型之间的复杂相互作用，与我们之前在多形核白细胞上得到的结果相似。儿茶酚胺对脂氧合酶和环氧化酶途径显示出相反的作用，这可能会在存在足够浓度儿茶酚胺的生理或病理条件下导致LT/TX比值发生显著变化。
