Kerttula T, Riutta A, Kaukinen S, Metsä-Ketelä T, Seppälä E, Vapaatalo H, Alanko J
Department of Clinical Chemistry, Tampere University Hospital, Finland.
Prostaglandins Leukot Essent Fatty Acids. 1995 Jul;53(1):47-52. doi: 10.1016/0952-3278(95)90082-9.
We have previously demonstrated that adrenaline infusion increases the thromboxane/leukotriene (TX/LT) ratio in whole blood in healthy volunteers. The aim of the present study was to see whether other catecholamines--noradrenaline and dopamine--are also capable of modulating arachidonic acid (AA) metabolism in man. Low doses of noradrenaline (0.025 microgram/kg/min) and dopamine (3.0 micrograms/kg/min), which did not change hemodynamics, were infused for 60 min into healthy male volunteers. Both dopamine and noradrenaline decreased TX synthesis stimulated by spontaneous clotting, but no remarkable effect was seen when calcium ionophore A23187 was used as a stimulus. Dopamine but not noradrenaline increased prostaglandin E2 (PGE2) synthesis in A23187-stimulated whole blood. They both marginally decreased LTB4 formation in A23187-stimulated whole blood. The findings indicate that not only adrenaline but also noradrenaline and dopamine modulate AA metabolism in man.
我们之前已经证明，在健康志愿者中，输注肾上腺素会增加全血中血栓素/白三烯（TX/LT）的比例。本研究的目的是观察其他儿茶酚胺——去甲肾上腺素和多巴胺——是否也能够调节人体中的花生四烯酸（AA）代谢。将不会改变血流动力学的低剂量去甲肾上腺素（0.025微克/千克/分钟）和多巴胺（3.0微克/千克/分钟）输注到健康男性志愿者体内60分钟。多巴胺和去甲肾上腺素均降低了自发凝血刺激的TX合成，但当使用钙离子载体A23187作为刺激物时，未观察到显著影响。在A23187刺激的全血中，多巴胺而非去甲肾上腺素增加了前列腺素E2（PGE2）的合成。它们都略微降低了A23187刺激的全血中LTB4的形成。这些发现表明，不仅肾上腺素，去甲肾上腺素和多巴胺也能调节人体中的AA代谢。
