人类对减毒活水痘疫苗的免疫反应。

Human immune responses to live attenuated varicella vaccine.

作者信息

Gershon A A

机构信息

Department of Pediatrics, Columbia University, College of Physicians and Surgeons, New York, New York 10032.

出版信息

Rev Infect Dis. 1991 Nov-Dec;13 Suppl 11:S957-9. doi: 10.1093/clind/13.supplement_11.s957.

DOI:10.1093/clind/13.supplement_11.s957

PMID:1664134

Abstract

Experiences with the use of the live attenuated varicella vaccine for the immunization of varicella-susceptible adults and healthy and leukemic children are described. Healthy children, for whom a greater than 90% rate of seroconversion and protective efficacy was noted, showed the best response. Leukemic children experienced a 40%-50% rate of vaccine-associated rash; protective efficacy approached 90%. For adults, a 10% rate of vaccine-associated rash and a protective efficacy of 70% were noted. Breakthrough cases of vaccine were mild, indicating modification of the course of the illness by the vaccine.

摘要

描述了使用减毒活水痘疫苗对易感水痘的成人、健康儿童和白血病儿童进行免疫接种的经验。健康儿童的血清转化率和保护效力高于90%，表现出最佳反应。白血病儿童出现疫苗相关皮疹的比例为40%-50%；保护效力接近90%。对于成人，疫苗相关皮疹的比例为10%，保护效力为70%。疫苗突破性病例症状较轻，表明疫苗改变了疾病进程。