Guo J A, Wang X Y, Dai L M
Institute of Basic Medical Sciences of Liaoning Province, Shenyang, China.
Zhongguo Yao Li Xue Bao. 1991 May;12(3):226-8.
Twelve health adults (6 M, 6 F) from the endemic area of Keshan disease and Kaschin-Beck's disease and 12 adults from nonaffected area were administered a single oral dose of 4 mg sodium selenite. Selenium in whole blood was determined by fluorescence spectrometry. Their basic levels of blood selenium were 64 +/- 16 and 220 +/- 20 ng.ml-1, respectively. The concentration-time data were treated by a computer with program 3P87, which revealed 2-compartment models with first order absorption and lag time. The pharmacokinetic parameters of low-Se group were T1/2g 1.8 +/- 0.6h, T1/2g 72 +/- 18 h, T1/2ka 3.2 +/- 1.8h, AUC 3,100 +/- 500 ng.h.ml-1, CL 32 +/- 7 ml.kg-1.h-1, Vc 1.45 +/- 0.19 L.kg-1, Tp 6.1 +/- 2.0 h, Cp 36 +/- 4 ng.ml-1, AUMC (S1) 130 +/- 26, VRT 174 +/- 17 h, MRT 55 +/- 4 h, and of normal-Se group were T1/2 3.4 +/- 0.7h, T1/2g 14 +/- 3 h. T1/2ka 2.3 +/- 0.6, AUC 1,420 +/- 210 ng.h.ml-1, Cl 57 +/- 7 ml.kg-1. h-1, Vc 0.54 +/- 0.09 L.kg-1, Tp 4.6 +/- 0.9h, Cp 75 +/- 5 ng.ml-1, AUMC (S1) 25 +/- 5, VRT 16 +/- 3 h, MRT 16.1 +/- 1.5 h.
选取12名来自克山病和大骨节病流行区的健康成年人（6名男性，6名女性）以及12名来自非病区的成年人，单次口服4毫克亚硒酸钠。采用荧光光谱法测定全血中的硒含量。他们的血硒基础水平分别为64±16和220±20纳克/毫升。浓度-时间数据用计算机程序3P87处理，结果显示为具有一级吸收和滞后时间的二室模型。低硒组的药代动力学参数为：T1/2g 1.8±0.6小时，T1/2g 72±18小时，T1/2ka 3.2±1.8小时，AUC 3100±500纳克·小时/毫升，CL 32±7毫升·千克-1·小时-1，Vc 1.45±0.19升/千克，Tp 6.1±2.0小时，Cp 36±4纳克/毫升，AUMC（S1）130±26，VRT 174±17小时，MRT 55±4小时；正常硒组的药代动力学参数为：T1/2 3.4±0.7小时，T1/2g 14±3小时，T1/2ka 2.3±0.6，AUC 1420±210纳克·小时/毫升，Cl 57±7毫升·千克-1·小时-1，Vc 0.54±0.09升/千克，Tp 4.6±0.9小时，Cp 75±5纳克/毫升，AUMC（S1）25±5，VRT 16±3小时，MRT 16.1±1.5小时。
