Tosun G, Sener Y
Faculty of Dentistry, Department of Pediatric Dentistry, Selcuk University, Konya, Turkey.
Int J Paediatr Dent. 2006 May;16(3):218-21. doi: 10.1111/j.1365-263X.2006.00696.x.
Apert syndrome is characterized by midface hypoplasia, syndactyly of the hands and feet, proptosis of eyes, steep and flat frontal bones, and premature union of cranial sutures. Maxillary hypoplasia, deep palatal vault, anterior open bite, crowding of the dental arch, severely delayed tooth eruption, and dental malocclusion are the main oral manifestations of this syndrome. In this report, a case of Apert syndrome with glucose-6-phosphate dehydrogenase (G(6)PD) deficiency is presented. The patient, a 4-year-old male and the fourth child of healthy parents, was admitted to our department because of delayed tooth eruption. He had all the cardinal symptoms of the Apert syndrome. Clinical examination revealed that primary centrals, canines and first molars erupted; however, primary second molars and laterals had not erupted. The patient had no dental caries. Preventive treatments were applied, and subsequently, the patient was taken to long-term follow up.
Apert综合征的特征为面中部发育不全、手足并指（趾）、眼球突出、额骨陡峭扁平以及颅缝过早闭合。上颌骨发育不全、腭穹窿深、前牙开（牙合）、牙弓拥挤、牙齿萌出严重延迟以及牙列不齐是该综合征的主要口腔表现。在本报告中，呈现了1例伴有葡萄糖-6-磷酸脱氢酶（G(6)PD）缺乏的Apert综合征病例。该患者为一名4岁男性，是健康父母的第四个孩子，因牙齿萌出延迟入住我科。他具备Apert综合征的所有主要症状。临床检查发现，乳中切牙、尖牙和第一乳磨牙已萌出；然而，乳第二磨牙和乳侧切牙尚未萌出。该患者无龋齿。实施了预防性治疗，随后对患者进行长期随访。
