双黄酮抑制再生肝脏磷酸酶-3（PRL-3）。

Biflavonoids inhibited phosphatase of regenerating liver-3 (PRL-3).

作者信息

Choi Sung-Kyu, Oh Hyun-Mi, Lee Su-Kyung, Jeong Dae Gwin, Ryu Seong Eon, Son Kwang-Hee, Han Dong Cho, Sung Nack-Do, Baek Nam-In, Kwon Byoung-Mog

机构信息

Korea Research Institute of Bioscience and Biotechnology, 52 Uendong, Yusung, Taejon 305-600, Republic of Korea.

出版信息

Nat Prod Res. 2006 Apr;20(4):341-6. doi: 10.1080/14786410500463312.

DOI:10.1080/14786410500463312

PMID:16644528

Abstract

Two biflavonoids, ginkgetin (1) and sciadopitysin (2), were isolated from the MeOH extract of the young branches of Taxus cuspidata, which inhibited phosphatase of regenerating liver-3 (PRL-3) with IC50 values of 25.8 and 46.2 microM, respectively. This is the first report on PRL-3 inhibitors, isolated from natural sources.

摘要

从东北红豆杉幼枝的甲醇提取物中分离出两种双黄酮，银杏双黄酮（1）和穗花杉双黄酮（2），它们对再生肝脏磷酸酶-3（PRL-3）具有抑制作用，IC50值分别为25.8和46.2微摩尔。这是首次报道从天然来源分离出的PRL-3抑制剂。