Booth Nancy L, Piersen Colleen E, Banuvar Suzanne, Geller Stacie E, Shulman Lee P, Farnsworth Norman R
UIC/NIH Center for Botanical Dietary Supplements Research, Program for Collaborative Research in the Pharmaceutical Sciences (PCRPS), University of Illinois at Chicago, Chicago, IL 60612, USA.
Menopause. 2006 Mar-Apr;13(2):251-64. doi: 10.1097/01.gme.0000198297.40269.f7.
Red clover (Trifolium pratense L., Fabaceae) botanical dietary supplements have received much attention recently for their potential use in the treatment of menopause symptoms, maintenance/improvement of bone and cardiovascular health, and reported benign effects on the breast and endometrium. Literature searches of four computerized databases were run to identify clinical studies of red clover botanical dietary supplements. The manufacturer of the red clover products used in the majority of the studies was contacted for unpublished information and/or clarification regarding the chemical content of their products. Red clover studies were reviewed that pertained to women's health or menopause. Clinical evidence is presently lacking to support the efficacy of semipurified red clover isoflavone extracts for alleviation of climacteric vasomotor symptoms or reduction of low-density lipoprotein levels in the blood. Furthermore, the safety of use of red clover isoflavone supplements in patients with breast or endometrial cancer has not been established. Limited evidence suggests possible efficacy in maintenance of bone health and improvement of arterial compliance, a risk factor for atherosclerosis. This literature review covers red clover botanical dietary supplement clinical studies having a possible impact on the health care of mature and menopausal women, and provides historical perspective regarding the traditional uses of red clover.
红三叶草（Trifolium pratense L.，豆科）植物性膳食补充剂最近备受关注，因为它们可能用于治疗更年期症状、维持/改善骨骼和心血管健康，以及据称对乳房和子宫内膜有良性作用。对四个计算机化数据库进行了文献检索，以确定红三叶草植物性膳食补充剂的临床研究。与大多数研究所用红三叶草产品的制造商联系，以获取未发表的信息和/或关于其产品化学成分的澄清。对涉及女性健康或更年期的红三叶草研究进行了综述。目前缺乏临床证据支持半纯化红三叶草异黄酮提取物缓解更年期血管舒缩症状或降低血液中低密度脂蛋白水平的疗效。此外，红三叶草异黄酮补充剂在乳腺癌或子宫内膜癌患者中的使用安全性尚未确立。有限的证据表明，在维持骨骼健康和改善动脉顺应性（动脉粥样硬化的一个危险因素）方面可能有效。这篇文献综述涵盖了对成熟和更年期女性医疗保健可能有影响的红三叶草植物性膳食补充剂临床研究，并提供了关于红三叶草传统用途的历史观点。
