Koch V Wensley
USDA, APHIS, Animal Care.
Lab Anim (NY). 2006 May;35(5):27-32. doi: 10.1038/laban0506-27.
Federal regulations mandate the minimization of both pain and distress in laboratory animals. That no clear definition exists for 'distress' complicates its recognition, quantification, and alleviation. The author argues that IACUCs and investigators should shift their focus from pain to distress, and that in doing so both problems will be better dealt with. She discusses criteria for defining 'significant' distress, and offers suggestions for the conduct of studies to determine levels of distress.
联邦法规要求将实验动物的疼痛和痛苦降至最低。由于对“痛苦”没有明确的定义，这使得对其的识别、量化和缓解变得复杂。作者认为，机构动物护理和使用委员会（IACUCs）及研究人员应将重点从疼痛转移到痛苦上，这样做两个问题都能得到更好的处理。她讨论了定义“严重”痛苦的标准，并为开展确定痛苦程度的研究提供了建议。
