Chwist-Nowak Aleksandra, Rozentryt Piotr, Chwist Jerzy, Jarzab Jerzy
Katedry i Oddziału Klinicznego Chorób Wewnetrznych i Dermatologii w Zabrzu Slaskiej Akademii Medycznej w Katowicach.
Wiad Lek. 2006;59(1-2):84-8.
Weight loss is a characteristic feature of chronic obstructive pulmonary disease (COPD) and a negative, independent predictor of outcome. It is a consequence of a misbalance between protein synthesis and breakdown resulting from increased energy requirement unbalanced by dietary intake. A depletion of fat-free mass is seen, especially in muscles (up to 60% of their mass) and leads to the loss of their power and endurance. The impairment of quality of life is very distinct. So far, there is no systemic treatment in cachectic patients with COPD, anti-catabolic treatment by polyunsaturated fatty acid may be of significance but needs further investigation.
体重减轻是慢性阻塞性肺疾病（COPD）的一个特征性表现，也是预后不良的独立负面预测因素。它是能量需求增加而饮食摄入无法平衡导致蛋白质合成与分解失衡的结果。可见去脂体重减少，尤其是肌肉（高达其质量的60%），并导致其力量和耐力丧失。生活质量受损非常明显。到目前为止，COPD恶病质患者尚无系统性治疗方法，多不饱和脂肪酸的抗分解代谢治疗可能有意义，但需要进一步研究。
