Takano T, Ohno M, Yamano T, Shimada M
Department of Pediatrics, Shiga University of Medical Science, Ohtsu, Japan.
Brain Dev. 1991 Sep;13(5):371-3. doi: 10.1016/s0387-7604(12)80138-0.
The possible occurrence of congenital hydrocephalus by viral infection of the mother was examined by inoculating pregnant hamsters intravenously with parainfluenza virus type 3 (PIV-3). We could produce congenital hydrocephalus in littermates born to a mother which had been inoculated into the left cervical vein on the 14th day of pregnancy. This result may indicate that the virus could pass through the placenta to arrive at the fetus, and infect the central nervous system.
通过给怀孕的仓鼠静脉注射3型副流感病毒（PIV - 3），研究母体病毒感染导致先天性脑积水的可能性。我们能够在怀孕第14天经左颈静脉接种病毒的母鼠所生的同窝幼崽中诱发先天性脑积水。这一结果可能表明病毒可穿过胎盘到达胎儿，并感染中枢神经系统。
