Aoki Daisuke, Takegoshi Hideki, Kikuchi Shigeru
Department of Otorhinolaryngology, Saitama Medical Center, Saitama Medical School, Saitama, Japan.
Otolaryngol Head Neck Surg. 2006 May;134(5):783-7. doi: 10.1016/j.otohns.2005.12.029.
To determine the efficacy of a high-dose steroid regimen for patients with sudden sensorineural hearing loss (SSNHL) and to evaluate the relationship between outcome and initial steroid dose.
We conducted a retrospective study of 112 patients presenting to Saitama Medical Center. Patients received tapering courses of hydrocortisone (HC) with an initial dose of either 1200 mg or 600 mg.
More than 87% of patients had recovery of hearing. When hearing stabilized, there were no significant differences between the 1200 mg and 600 mg groups in terms of hearing outcome (P>0.05). However, at completion of treatment, the 1200 mg group exhibited significantly superior complete recovery rate and improvement rate (P<0.05).
Application of our treatment protocol of a tapered course of 1200 mg HC significantly and rapidly improves recovery outcomes in patients of SSNHL.
C-4.
确定高剂量类固醇方案对突发性感音神经性听力损失（SSNHL）患者的疗效，并评估治疗结果与初始类固醇剂量之间的关系。
我们对埼玉医疗中心的112例患者进行了一项回顾性研究。患者接受了初始剂量为1200毫克或600毫克的氢化可的松（HC）递减疗程治疗。
超过87%的患者听力得到恢复。听力稳定时，1200毫克组和600毫克组在听力结果方面无显著差异（P>0.05）。然而，在治疗结束时，1200毫克组的完全恢复率和改善率显著更高（P<0.05）。
应用我们的1200毫克HC递减疗程治疗方案可显著且迅速地改善SSNHL患者的恢复结果。
C-4。
