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高压氧疗法作为突发性感音神经性听力损失皮质类固醇治疗的辅助手段:一项回顾性研究。

Hyperbaric oxygen therapy as an adjunct to corticosteroid treatment in sudden sensorineural hearing loss: a retrospective study.

作者信息

Skarzynski Piotr H, Kolodziejak Aleksandra, Gos Elżbieta, Skarzynska Magdalena B, Czajka Natalia, Skarzynski Henryk

机构信息

Department of Teleaudiology and Screening, World Hearing Center, Institute of Physiology and Pathology of Hearing, Kajetany/Warsaw, Poland.

Heart Failure and Cardiac Rehabilitation Department, Faculty of Medicine, Medical University of Warsaw, Warsaw, Poland.

出版信息

Front Neurol. 2023 Jul 5;14:1225135. doi: 10.3389/fneur.2023.1225135. eCollection 2023.

DOI:10.3389/fneur.2023.1225135
PMID:37475734
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10354245/
Abstract

BACKGROUND

A retrospective clinical study was conducted to test the impact of including hyperbaric oxygen therapy in the treatment of patients with sudden sensorineural hearing loss (SSNHL).

MATERIALS AND METHODS

A total of 63 adult patients with sudden sensorineural hearing loss diagnosed between 2015 and 2023 were divided into two groups: 36 patients treated with intratympanic glucocorticoid and orally administered glucocorticoid who also underwent hyperbaric oxygen therapy and 27 patients treated with intratympanic glucocorticoid and prolonged orally administered glucocorticoid (without hyperbaric oxygen therapy). An audiological evaluation was performed using pure-tone audiometry.

RESULTS

Average hearing gain as measured by pure tone average was 12.5 dB HL (+/- 19.9 dB HL) in the patients treated with steroids combined with HBOT, and was 14.1 dB HL (+/- 17.9 dB) in the patients treated with steroids alone. Successful treatment (complete recovery or marked improvement) was observed in 27.8% of the patients in the first group and in 25.5% in the second group. There was no statistically significant difference between the groups.

CONCLUSION

Both groups of patients-those treated with glucocorticoids and those treated with glucocorticoids and HBOT-had similar hearing outcomes. A prospective, controlled, and randomized study would provide more reliable knowledge about the efficacy of HBOT in treating SSNHL.

摘要

背景

进行了一项回顾性临床研究,以测试高压氧治疗对突发性感音神经性听力损失(SSNHL)患者治疗效果的影响。

材料与方法

共有63例在2015年至2023年期间被诊断为突发性感音神经性听力损失的成年患者被分为两组:36例接受鼓室内糖皮质激素和口服糖皮质激素治疗且同时接受高压氧治疗的患者,以及27例接受鼓室内糖皮质激素和延长口服糖皮质激素治疗(未接受高压氧治疗)的患者。使用纯音听力计进行听力评估。

结果

在接受类固醇联合高压氧治疗的患者中,通过纯音平均值测量的平均听力增益为12.5 dB HL(±19.9 dB HL),而在仅接受类固醇治疗的患者中为14.1 dB HL(±17.9 dB)。第一组27.8%的患者和第二组25.5%的患者观察到治疗成功(完全恢复或显著改善)。两组之间无统计学显著差异。

结论

两组患者——接受糖皮质激素治疗的患者和接受糖皮质激素及高压氧治疗的患者——听力结果相似。一项前瞻性、对照和随机研究将提供关于高压氧治疗SSNHL疗效的更可靠知识。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a2e/10354245/b5580d78b935/fneur-14-1225135-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a2e/10354245/e10790902fdd/fneur-14-1225135-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a2e/10354245/b5580d78b935/fneur-14-1225135-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a2e/10354245/e10790902fdd/fneur-14-1225135-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a2e/10354245/b5580d78b935/fneur-14-1225135-g002.jpg

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