中国老年人群中饮酒与心房颤动发病率的关系。

Alcohol consumption in relation to the incidence of atrial fibrillation in an elderly Chinese population.

作者信息

Ye Xiao-Fei, Zhang Wei, Chen Yi, Miao Chao-Ying, Huang Qi-Fang, Sheng Chang-Sheng, Shao Shuai, Wang Dian, Xu Shao-Kun, Lei Lei, Zhang Di, Chen Yi-Lin, Hu Lei-Xiao, Xia Jia-Hui, Cheng Yi-Bang, Wang Ying, Guo Qian-Hui, Li Yan, Lowres Nicole, Freedman Ben, Wang Ji-Guang

机构信息

School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Department of Cardiovascular Medicine, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

出版信息

J Geriatr Cardiol. 2022 Jan 28;19(1):52-60. doi: 10.11909/j.issn.1671-5411.2022.01.005.

DOI:10.11909/j.issn.1671-5411.2022.01.005

PMID:35233223

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8832043/

Abstract

BACKGROUND

Alcohol consumption is a known modifiable risk factor for atrial fibrillation. The association, however, might differ according to gender. We investigated gender-specific associations between alcohol consumption and incident atrial fibrillation in an elderly Chinese population.

METHODS

Our study participants were elderly residents (≥ 65 years) recruited from five community health centers in the urban area of Shanghai ( = 6,618). Alcohol intake was classified as never drinkers and current light-to-moderate (< 40 g/day) and heavy drinkers (≥ 40 g/day). Atrial fibrillation was detected by a 30-s single-lead electrocardiography (ECG, AliveCor Heart Monitor) and further evaluated with a regular 12-lead ECG.

RESULTS

During a median of 2.1 years (interquartile range: 2.0-2.2) follow-up, the incidence rate of atrial fibrillation was 1.10% in all study participants. It was slightly but non-significantly higher in men ( = 2849) than women ( = 3769, 1.30% . 0.96%, = 0.19) and in current drinkers ( = 793) than never drinkers ( = 5825, 1.64% . 1.03%, = 0.12). In both unadjusted and adjusted analyses, there was interaction between sex and current alcohol intake in relation to the incidence of atrial fibrillation ( < 0.0001). After adjustment for confounding factors, current drinkers had a significantly higher incidence rate of atrial fibrillation than never drinkers in women (12.96% [7/54] . 0.78% [29/3715], adjusted odds ratio [OR] = 10.25, 95% confidence interval [CI]: 3.54-29.67, < 0.0001), but not in men (0.81% [6/739] . 1.47% [31/2110], OR = 0.62, 95% CI: 0.25-1.51, = 0.29).

CONCLUSIONS

Our study showed a significant association between alcohol intake and the incidence of atrial fibrillation in elderly Chinese women, but not men.

摘要

背景

饮酒是已知的心房颤动可改变风险因素。然而，这种关联可能因性别而异。我们调查了中国老年人群中饮酒与新发心房颤动之间的性别特异性关联。

方法

我们的研究参与者是从上海市区五个社区卫生中心招募的老年居民（≥65岁，n = 6618）。饮酒情况分为从不饮酒者、当前轻度至中度饮酒者（<40克/天）和重度饮酒者（≥40克/天）。通过30秒单导联心电图（ECG，AliveCor心脏监测仪）检测心房颤动，并进一步用常规12导联心电图进行评估。

结果

在中位2.1年（四分位间距：2.0 - 2.2）的随访期间，所有研究参与者中心房颤动的发病率为1.10%。男性（n = 2849）的发病率略高于女性（n = 3769，分别为1.30%和0.96%，P = 0.19），当前饮酒者（n = 793）的发病率高于从不饮酒者（n = 5825，分别为1.64%和1.03%，P = 0.12），但差异均无统计学意义。在未调整和调整分析中，性别与当前饮酒量在心房颤动发病率方面存在交互作用（P < 0.0001）。在调整混杂因素后，当前饮酒者中心房颤动的发病率在女性中显著高于从不饮酒者（12.96% [7/54]对0.78% [29/3715]，调整后比值比[OR] = 10.25，95%置信区间[CI]：3.54 - 29.67，P < 0.0001），而在男性中并非如此（0.81% [6/739]对1.47% [31/2110]，OR = 0.62，95% CI：0.25 - 1.51，P = 0.29）。