Karkos Petros D, Leong Samuel C, Apostolidou Maria T, Apostolidis Theocharis
Department of Otolaryngology, Alder Hey Children's Hospital, Liverpool, UK.
Am J Otolaryngol. 2006 May-Jun;27(3):200-3. doi: 10.1016/j.amjoto.2005.09.004.
Pediatric laryngopharyngeal reflux (PLPR) refers to the atypical, otorhinolaryngological, and respiratory manifestations of gastroesophageal reflux disease in children. PLPR is believed to be an important inflammatory cofactor in disorders such as subglottic stenosis, asthma, recurrent croup, chronic rhinosinusitis, and middle ear infections. We review the literature, present clinical manifestations, and focus on diagnostic controversies and therapeutic challenges of PLPR in relation to laryngeal manifestations. Current evidence linking reflux to many laryngeal problems is mainly based on animal studies or uncontrolled human studies. Future efforts should concentrate on developing well-designed controlled studies to provide more information on diagnosis and treatment.
小儿喉咽反流（PLPR）是指小儿胃食管反流病的非典型、耳鼻喉科及呼吸道表现。PLPR被认为是诸如声门下狭窄、哮喘、复发性喉炎、慢性鼻窦炎和中耳感染等疾病的重要炎症协同因素。我们回顾了相关文献，介绍了临床表现，并重点关注PLPR在喉部表现方面的诊断争议和治疗挑战。目前将反流与许多喉部问题联系起来的证据主要基于动物研究或非对照人体研究。未来的工作应集中于开展设计良好的对照研究，以提供更多关于诊断和治疗的信息。
