Košec Andro, Žaja Orjena, Matovinović Filip, Jelavić Boris, Baudoin Tomislav
Department of Otorhinolarygology and Head and Neck Surgery, University Clinical Hospital Centre Sestre Milosrdnice, Zagreb University School of Medicine, Zagreb, Croatia.
Department of Pediatrics, University Clinical Hospital Centre Sestre Milosrdnice, Zagreb University School of Medicine, Zagreb, Croatia.
Int Arch Otorhinolaryngol. 2020 Oct;24(4):e472-e476. doi: 10.1055/s-0039-3402437. Epub 2020 Feb 7.
Current practice guidelines in gastroesophageal reflux disease (GERD) often require invasive diagnostic testing. The aim of the present study was to evaluate the significance of extra-esophageal symptoms and reliability of a screening risk score that is simple to use. A longitudinal retrospective single-institution cohort study. Setting: A university clinical hospital tertiary referral center. The present study enrolled pediatric patients with symptoms suggestive of GERD: epigastric pain, occasional nausea, regurgitation, tasting acid in the oral cavity, chronic cough, hoarseness of voice, frequent throat clearing. The patients underwent 24-hour esophageal pH monitoring and fiber-optic laryngoscopy. The correlations between the local findings, anamnestic and objective measurement data were analyzed. The present study evaluated 89 pediatric patients. Patients with asthma presented significantly more often with adjoining gastrointestinal symptoms ( = 0.0472). Patients that were obese were linked to a higher rate of reports of gastrointestinal symptoms ( = 0.0495). After the patients had been assigned to newly developed risk groups, obesity showed to be significantly more frequent in patients placed in higher risk groups ( < 0.0001) for a positive GERD diagnosis. Patients with leading symptoms of asthma presented significantly more often with adjoining gastrointestinal symptoms. Obesity showed to be significantly more frequent in patients placed in higher risk groups for a positive GERD diagnosis.
目前胃食管反流病（GERD）的临床实践指南通常需要进行侵入性诊断测试。本研究的目的是评估食管外症状的意义以及一种易于使用的筛查风险评分的可靠性。这是一项纵向回顾性单机构队列研究。研究地点：一家大学临床医院三级转诊中心。本研究纳入了有GERD症状提示的儿科患者：上腹部疼痛、偶尔恶心、反流、口腔内有酸味、慢性咳嗽、声音嘶哑、频繁清嗓。患者接受了24小时食管pH监测和纤维喉镜检查。分析了局部检查结果、既往史和客观测量数据之间的相关性。本研究评估了89例儿科患者。哮喘患者出现相邻胃肠道症状的频率明显更高（P = 0.0472）。肥胖患者胃肠道症状报告率更高（P = 0.0495）。在将患者分配到新开发的风险组后，肥胖在GERD诊断阳性的高风险组患者中明显更为常见（P < 0.0001）。有哮喘主要症状的患者出现相邻胃肠道症状的频率明显更高。肥胖在GERD诊断阳性的高风险组患者中明显更为常见。
