Chen Ming, Geng Jian-Guo
Laboratory of Molecular Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Graduate School of Chinese Academy of Sciences, Shanghai, 200031, China.
Arch Immunol Ther Exp (Warsz). 2006 Mar-Apr;54(2):75-84. doi: 10.1007/s00005-006-0010-6. Epub 2006 Mar 24.
Stimulated endothelial cells and activated platelets express P-selectin (CD62P), a member of the selectin family of cell adhesion molecules, which interacts with P-selectin glycoprotein ligand-1 (PSGL-1, CD162) for leukocyte rolling on stimulated endothelial cells and heterotypic aggregation of activated platelets onto leukocytes. Cross-linking of PSGL-1 by P-selectin also primes leukocytes intracellularly for cytokine and chemoattractant-induced beta2-integrin activation for firm adhesion of leukocytes. Furthermore, P-selectin mediates heterotypic aggregation of activated platelets to cancer cells and adhesion of cancer cells to stimulated endothelial cells. Here we provide a comprehensive summary of the functional roles and the biological importance of P-selectin-mediated cell adhesive interactions in the pathogeneses of inflammation, thrombosis, and the growth and metastasis of cancers.
受刺激的内皮细胞和活化的血小板表达P-选择素（CD62P），它是细胞黏附分子选择素家族的一员，可与P-选择素糖蛋白配体-1（PSGL-1，CD162）相互作用，使白细胞在受刺激的内皮细胞上滚动，并使活化的血小板异型聚集到白细胞上。P-选择素对PSGL-1的交联还在细胞内使白细胞对细胞因子和趋化因子诱导的β2整合素激活做好准备，以实现白细胞的牢固黏附。此外，P-选择素介导活化的血小板与癌细胞的异型聚集以及癌细胞与受刺激的内皮细胞的黏附。在此，我们全面总结了P-选择素介导的细胞黏附相互作用在炎症、血栓形成以及癌症生长和转移发病机制中的功能作用和生物学重要性。
