Hall Mei Hua, Schulze Katja, Bramon Elvira, Murray Robin M, Sham Pak, Rijsdijk Frühling
Social, Genetic Developmental Psychiatry Research Centre, Institute of Psychiatry, King's College London, London, United Kingdom.
Am J Med Genet B Neuropsychiatr Genet. 2006 Jun 5;141B(4):336-43. doi: 10.1002/ajmg.b.30318.
Mismatch Negativity (MMN), P300, and P50 suppression event-related potential (ERP) components measure intermediate stages of information processing but little is known of how they relate to each other genetically. The present study used multivariate genetic model fitting analytic techniques in 46 monozygotic and 32 dizygotic twin pairs. P300, P50 suppression, and MMN were recorded using a 19-channel electroencephalograph (EEG). Zygosity was determined using DNA genotyping. Little evidence for either genetic or environmental association between each of the three ERP paradigms was found. This result suggests that P300, MMN, and P50 suppression serve to evaluate different brain information processing functions that may be mediated by distinct neurobiological mechanisms which in turn are influenced by different sets of genes. Within paradigm, P300 amplitude and latency shared about half of their genetic effects.
失匹配负波（MMN）、P300和P50抑制事件相关电位（ERP）成分可测量信息处理的中间阶段，但对于它们在基因层面如何相互关联却知之甚少。本研究对46对同卵双胞胎和32对异卵双胞胎使用了多变量遗传模型拟合分析技术。使用19通道脑电图仪（EEG）记录P300、P50抑制和MMN。通过DNA基因分型确定双胞胎的合子性。未发现这三种ERP范式之间存在遗传或环境关联的证据。该结果表明，P300、MMN和P50抑制用于评估不同的大脑信息处理功能，这些功能可能由不同的神经生物学机制介导，而这些机制又受到不同基因集的影响。在范式内，P300的波幅和潜伏期约有一半的遗传效应是共享的。
