Watanabe T, Morimoto A, Murakami N
Department of Physiology, Yamaguchi University, School of Medicine, Japan.
Pflugers Arch. 1991 Dec;419(6):629-31. doi: 10.1007/BF00370306.
The present study was carried out to compare the threshold doses of interleukin-1 beta (IL-1 beta) necessary to elicit febrile and adrenocorticotrophic hormone (ACTH) responses. The results show that intravenous injection of a small dose of IL-1 beta (0.2 micrograms/kg) did not stimulate ACTH secretion but induced a significant febrile response. However, intravenous injection of a higher dose of IL-1 beta (2.0 micrograms/kg) induced significant increases in plasma ACTH accompanying the fever. These results suggest that the rise in body temperature per se is not responsible for the ACTH response and that the threshold dose of IL-1 beta to induce the ACTH response is higher than that to elicit the febrile response.
本研究旨在比较引发发热反应和促肾上腺皮质激素（ACTH）反应所需的白细胞介素-1β（IL-1β）的阈值剂量。结果表明，静脉注射小剂量的IL-1β（0.2微克/千克）不会刺激ACTH分泌，但会引起显著的发热反应。然而，静脉注射较高剂量的IL-1β（2.0微克/千克）会在发热的同时引起血浆ACTH显著升高。这些结果表明，体温升高本身并非ACTH反应的原因，诱导ACTH反应的IL-1β阈值剂量高于引发发热反应的阈值剂量。
