Boyle R J, Tang M L K
Murdoch Children's Research Institute, Royal Children's Hospital, Flemington Road, Parkville, Vic., Australia.
Clin Exp Allergy. 2006 May;36(5):568-76. doi: 10.1111/j.1365-2222.2006.02472.x.
Probiotics have recently been advocated for the prevention and treatment of allergic disease (AD). In clinical practice they are increasingly being used for these purposes. Here we review the evidence base for the use of probiotics in the management of AD. We find support for their use in the treatment of childhood eczema, but the clinical significance of any treatment effect is uncertain. There is also evidence to support the use of probiotics in the prevention of childhood eczema. However the available evidence suggests that probiotics are not an effective treatment for allergic airway diseases. Probiotics may be more effective when used early in life, and they may have a particular role in gastrointestinal AD. The relative efficacy of different probiotic strains in the management of AD is not well established, and further work is needed to establish their mechanisms of action. In summary probiotics are likely to play a part in the management of childhood eczema in the future, and further studies are warranted to precisely define their role.
益生菌最近被提倡用于预防和治疗过敏性疾病（AD）。在临床实践中，它们越来越多地被用于这些目的。在此，我们回顾了益生菌用于AD管理的证据基础。我们发现其在治疗儿童湿疹方面有依据支持，但任何治疗效果的临床意义尚不确定。也有证据支持益生菌用于预防儿童湿疹。然而，现有证据表明益生菌并非治疗过敏性气道疾病的有效方法。益生菌在生命早期使用可能更有效，且它们在胃肠道AD中可能具有特殊作用。不同益生菌菌株在AD管理中的相对疗效尚未明确确立，需要进一步开展工作来确定其作用机制。总之，益生菌未来可能在儿童湿疹管理中发挥作用，有必要进行进一步研究以准确界定其作用。
