del Giudice Michele Miraglia, Rocco Adriana, Capristo Carlo
Department of Paediatrics, Second University, Naples, Italy.
Dig Liver Dis. 2006 Dec;38 Suppl 2:S288-90. doi: 10.1016/S1590-8658(07)60012-7.
The frequent development of allergic respiratory diseases in patients with histories of atopic dermatitis (AD) in early childhood has been known for a long time. At school age, AD has been associated with an increased risk of asthma, and was thus regarded as one of the first steps in a successive "atopic march" leading from AD to asthma. Probiotics are cultures of potentially beneficial bacteria that positively affect the host by enhancing the microbial balance and therefore restore the normal intestinal permeability and gut microecology. They also improve the intestine's immunological barrier function and reduce the generation of proinflammatory cytokines characteristic of allergic inflammation. In clinical trials probiotics appear to be useful for the treatment of various clinical conditions such as food allergy, AD and allergic rhinitis, and in primary prevention of atopy. We can hypothesize that it may be possible, in the future, to use probiotics in primary prevention of asthma.
长期以来，人们一直知道患有特应性皮炎（AD）病史的儿童经常会出现过敏性呼吸道疾病。在学龄期，AD与哮喘风险增加有关，因此被视为从AD到哮喘的连续“特应性进程”的第一步。益生菌是具有潜在益处的细菌培养物，通过增强微生物平衡对宿主产生积极影响，从而恢复正常的肠道通透性和肠道微生态。它们还能改善肠道的免疫屏障功能，减少过敏性炎症特有的促炎细胞因子的产生。在临床试验中，益生菌似乎对治疗各种临床病症如食物过敏、AD和过敏性鼻炎以及特应性疾病的一级预防有用。我们可以推测，未来有可能将益生菌用于哮喘的一级预防。
