Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Pediatr Allergy Immunol. 2010 Sep;21(6):900-19. doi: 10.1111/j.1399-3038.2009.00955.x. Epub 2009 Dec 9.
The prevalence of allergic diseases such as asthma, allergic rhinitis, and atopic dermatitis has increased sharply over the past two to three decades in many countries, and allergies are now the most common chronic disease among children throughout the world. In the past few years, probiotics have been advocated for the management of allergic diseases in many parts of the world. Physicians have a responsibility to ensure the efficacy and safety of any products they prescribe or recommend. This article provides a comprehensive overview and a critical interpretation of currently available evidence regarding the role of probiotics in the prevention and treatment of allergic diseases in humans and also discusses several major myths and potential risks associated with the use of probiotics. In the current era of evidence-based medicine, there is still insufficient evidence to recommend probiotics for the prevention of allergic diseases or as part of standard management for any allergic conditions in children.
在过去的二三十年中，许多国家的哮喘、过敏性鼻炎和特应性皮炎等过敏性疾病的患病率急剧上升，过敏现在是全世界儿童中最常见的慢性疾病。在过去的几年中，益生菌已在世界许多地方被提倡用于治疗过敏性疾病。医生有责任确保他们开出或推荐的任何产品的疗效和安全性。本文全面概述并批判性地解释了目前有关益生菌在预防和治疗人类过敏性疾病中的作用的现有证据，还讨论了与使用益生菌相关的几个主要误区和潜在风险。在当前基于证据的医学时代，仍然没有足够的证据推荐益生菌用于预防过敏性疾病，也不推荐将其作为儿童任何过敏情况的标准治疗方法的一部分。
