BioMedCom Consultants Inc., Montreal, QC, Canada.
BMC Infect Dis. 2012 Mar 19;12:62. doi: 10.1186/1471-2334-12-62.
Rotavirus affects 95% of children worldwide by age 5 years and is the leading cause of severe dehydrating diarrhea. The objective of this review was to estimate the burden of rotavirus gastroenteritis (RVGE) in the Western European pediatric population.
A comprehensive literature search (1999-2010) was conducted in PubMed and other sources (CDC; WHO, others). Data on the epidemiology and burden of RVGE among children < 5 years-old in Western Europe --including hospital-acquired disease--were extracted.
76 studies from 16 countries were identified. The mean percentage of acute gastroenteritis (AGE) cases caused by rotavirus ranged from 25.3%-63.5% in children < 5 years of age, peaking during winter. Incidence rates of RVGE ranged from 1.33-4.96 cases/100 person- years. Hospitalization rates for RVGE ranged from 7% to 81% among infected children, depending on the country. Nosocomial RVGE accounted for 47%-69% of all hospital-acquired AGE and prolonged hospital stays by 4-12 days. Each year, RVGE incurred $0.54- $53.6 million in direct medical costs and $1.7-$22.4 million in indirect costs in the 16 countries studied. Full serotyping data was available for 8 countries. G1P[8], G2P[4], G9P[8], and G3P[8] were the most prevalent serotypes (cumulative frequency: 57.2%- 98.7%). Serotype distribution in nosocomial RVGE was similar.
This review confirms that RVGE is a common disease associated with significant morbidity and costs across Western Europe. A vaccine protecting against multiple serotypes may decrease the epidemiological and cost burden of RVGE in Western Europe.
轮状病毒影响全球 95%的 5 岁以下儿童，是导致严重腹泻脱水的主要原因。本研究旨在评估西欧儿科人群中轮状病毒胃肠炎（RVGE）的疾病负担。
在 PubMed 和其他来源（美国疾病预防控制中心；世界卫生组织，其他）中进行了全面的文献检索（1999-2010 年）。提取了西欧<5 岁儿童中 RVGE 的流行病学和疾病负担的数据，包括医院获得性疾病。
从 16 个国家的 76 项研究中发现，<5 岁儿童中轮状病毒引起的急性胃肠炎（AGE）的平均百分比为 25.3%-63.5%，冬季达到高峰。轮状病毒胃肠炎的发病率为 1.33-4.96/100 人年。感染儿童的 RVGE 住院率因国家而异，为 7%-81%。医院获得性 RVGE 占所有医院获得性 AGE 的 47%-69%，并使住院时间延长 4-12 天。在研究的 16 个国家中，每年因 RVGE 导致的直接医疗费用为 0.54-53.6 百万美元，间接费用为 1.7-22.4 百万美元。8 个国家有完整的血清型数据。G1P[8]、G2P[4]、G9P[8]和 G3P[8]是最常见的血清型（累积频率：57.2%-98.7%）。医院获得性 RVGE 的血清型分布相似。
本研究证实，RVGE 在西欧是一种常见疾病，与发病率和费用有很大关系。针对多种血清型的疫苗可能会降低西欧 RVGE 的流行病学和费用负担。
