急性脊髓损伤中的甲基强的松龙治疗：通过对已发表文献的结构化分析挑战这一误区
Methylprednisolone treatment in acute spinal cord injury: the myth challenged through a structured analysis of published literature.
作者信息
Sayer Faisal T, Kronvall Erik, Nilsson Ola G
机构信息
Department of Neurosurgery, Lund University Hospital, Lund 221 85, Sweden.
出版信息
Spine J. 2006 May-Jun;6(3):335-43. doi: 10.1016/j.spinee.2005.11.001.
BACKGROUND CONTEXT
Methylprednisolone has evolved during the 1990s, through the results obtained from the National Acute Spinal Cord Injury Studies NASCIS II and III, as a standard treatment in acute spinal injury.
PURPOSE
To evaluate the scientific basic for the use of methylprednisolone in acute spinal cord injury.
STUDY DESIGN
Systematic review of the accumulated literature.
METHODS
Critical evaluation of the data obtained in the NASCIS II and III studies plus other accumulated literature.
RESULTS
Analyses have been made on subgroups of the study populations, and the results were based on statistical artefacts. Furthermore, improved functional recovery shown by these studies was not clinically significant.
CONCLUSION
There is insufficient evidence to support the use of methylprednisolone as a standard treatment in acute spinal cord injury.
背景
在20世纪90年代，通过国家急性脊髓损伤研究（NASCIS）II和III所取得的结果，甲基强的松龙已逐渐成为急性脊髓损伤的标准治疗药物。
目的
评估在急性脊髓损伤中使用甲基强的松龙的科学依据。
研究设计
对累积文献进行系统综述。
方法
对NASCIS II和III研究以及其他累积文献中获得的数据进行批判性评估。
结果
对研究人群的亚组进行了分析，结果基于统计假象。此外，这些研究显示的功能恢复改善在临床上并不显著。
结论
没有足够的证据支持将甲基强的松龙用作急性脊髓损伤的标准治疗药物。
Zotero 插件