Inglis David W, Davis John A, Austin Robert H, Sturm James C
Princeton Institute for the Science and Technology of Materials, PRISM Princeton University, Princeton, NJ 08544, USA.
Lab Chip. 2006 May;6(5):655-8. doi: 10.1039/b515371a. Epub 2006 Mar 17.
The fractionation of small particles in a liquid based on their size in a micropost array by deterministic lateral displacement was recently demonstrated with unprecedented resolution (L. R. Huang, E. C. Cox, R. H. Austin and J. C. Sturm, Science, 2004, 304, 987-990, ). In this paper, we present a model of how the critical particle size for fractionation depends on the micropost geometry, depending specifically on the gap between posts, the offset of posts in one row with respect to another, and whether the fluid is driven by hydrodynamics or by electroosmosis. In general the critical particle diameter is much smaller than the gap, which prevents clogging. The model is supported by data with particles from 2.3 to 22 microm.
最近，基于微柱阵列中液体中小颗粒的尺寸，通过确定性横向位移对其进行分级分离，已展现出前所未有的分辨率（L. R. 黄、E. C. 考克斯、R. H. 奥斯汀和J. C. 斯特姆，《科学》，2004年，第304卷，第987 - 990页）。在本文中，我们提出了一个模型，用于说明分级分离的临界颗粒尺寸如何取决于微柱几何形状，具体取决于柱间间隙、一行柱相对于另一行柱的偏移，以及流体是由流体动力学驱动还是由电渗驱动。一般来说，临界颗粒直径远小于间隙，这可防止堵塞。该模型得到了直径从2.3至22微米颗粒数据的支持。
