Erickson G A, Bolin S R, Landgraf J G
Rollins Animal Disease Diagnostic Laboratory, Raleigh, NC 27605.
Dev Biol Stand. 1991;75:173-5.
Four viral contaminants have been routinely detected in unprocessed and commercial lots of fetal bovine serum: bacteriophage, infectious bovine rhinotracheitis, parainfluenza-3 and bovine viral diarrhea virus (BVDV). Of those, BVDV is consistently present in a majority of commercial lots of fetal bovine serum. Methods for BVDV detection and removal are reviewed. The tentative role of an unclassified pestivirus in microcephaly of infants has been reported. Its significance remains uncertain.
在未加工的和商业批次的胎牛血清中，常规检测到四种病毒污染物：噬菌体、传染性牛鼻气管炎病毒、副流感-3病毒和牛病毒性腹泻病毒（BVDV）。其中，BVDV在大多数商业批次的胎牛血清中一直存在。本文综述了BVDV的检测和去除方法。有报道称一种未分类的瘟病毒在婴儿小头畸形中可能起作用，但其意义仍不确定。
