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孕期饮酒母亲所生后代的脑发育异常

[Dysontogenesis of the brain of the progeny born to mothers drinking alcohol during pregnancy].

作者信息

Kovetskiĭ N S, Konovalov G V, Orlovskaia D D, Semke V Ia, Solonskiĭ A V

出版信息

Zh Nevropatol Psikhiatr Im S S Korsakova. 1991;91(10):57-63.

PMID:1665654
Abstract

A study was made of the development of the brain from 44 embryos (5-12 weeks) and 1 fetus (14 weeks) obtained from mothers who used alcohol during pregnancy. 16 cases made up the control group. In 34 cases out of 45 (75.5%), deviations in the development of the brain were established and distributed into the three degrees of gravity: mild, moderate and severe. 11 variants of brain pathology are described. Deviations in the formation of brain walls and disorders of the development of the cortical lamina occurred most frequently (70.6 and 57.9%, respectively). In alcoholic mothers, brain pathology in their progeny was revealed in 100% of cases. Provided they used alcohol systematically and frequently, brain pathology was identified in 83.3% of cases, in systematic rare use of alcohol in 77.3%, and in episodic use of alcohol in 28.5% of cases.

摘要

对44例胚胎(5 - 12周)和1例胎儿(14周)的大脑发育情况进行了研究,这些胚胎和胎儿来自孕期饮酒的母亲。16例组成对照组。在45例中的34例(75.5%)中,发现大脑发育存在偏差,并分为轻度、中度和重度三个严重程度等级。描述了11种脑病理变体。脑壁形成偏差和皮质板发育障碍最为常见(分别为70.6%和57.9%)。在酗酒母亲的后代中,100%发现有脑病理情况。如果她们经常且有规律地饮酒,83.3%的病例可发现脑病理情况;如果有规律但很少饮酒,77.3%的病例可发现脑病理情况;如果偶尔饮酒,28.5%的病例可发现脑病理情况。

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