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1
Inhibition of Sterol Biosynthesis by 2-Isopropyl-4-dimethylamino-5-methylphenyl-1-piperidine Carboxylate Methyl Chloride in Tobacco and Rat Liver Preparations.2-异丙基-4-二甲基氨基-5-甲基苯基-1-哌啶羧酸甲酯盐酸盐在烟草和大鼠肝制剂中对甾醇生物合成的抑制作用。
Plant Physiol. 1972 Mar;49(3):417-20. doi: 10.1104/pp.49.3.417.
2
Cholinesterases from Plant Tissues: II. Inhibition of Bean Cholinesterase by 2-Isopropyl-4-dimethylamino-5-methylphenyl-1-piperidine Carboxylate Methyl Chloride (AMO-1618).植物组织中的胆碱酯酶：二、2-异丙基-4-二甲基氨基-5-甲基苯基-1-哌啶羧酸甲酯氯化物（AMO-1618）对豆类胆碱酯酶的抑制作用。
Plant Physiol. 1973 Sep;52(3):233-5. doi: 10.1104/pp.52.3.233.
3
Plant growth retardants as inhibitors of sterol biosynthesis in tobacco seedlings.植物生长延缓剂作为烟草幼苗中甾醇生物合成的抑制剂
Plant Physiol. 1974 Sep;54(3):238-45. doi: 10.1104/pp.54.3.238.
4
Inhibition of squalene synthase and squalene epoxidase in tobacco cells triggers an up-regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase.烟草细胞中角鲨烯合酶和角鲨烯环氧酶的抑制引发3-羟基-3-甲基戊二酰辅酶A还原酶的上调。
Plant Physiol. 2002 Sep;130(1):334-46. doi: 10.1104/pp.004655.
5
Sterol and sesquiterpenoid biosynthesis during a growth cycle of tobacco cell suspension cultures.甾醇和倍半萜生物合成在烟草细胞悬浮培养物的一个生长周期中。
Plant Cell Rep. 1989 May;8(1):48-52. doi: 10.1007/BF00735777.
6
The action of plant growth retardants on terpenoid biosynthesis : Inhibition of gibberellic-acid production inFusarium moniliforme by CCC and AMO-1618; Action of these retardants on sterol biosynthesis.植物生长延缓剂对萜类生物合成的作用：CCC 和 AMO-1618 对木霉菌产生赤霉素的抑制作用；这些延缓剂对甾醇生物合成的作用。
Planta. 1969 Jun;88(2):172-82. doi: 10.1007/BF01391123.
7
Inhibition of hepatic sterol and squalene biosynthesis in rats fed di-i-ethylhexyl phthalate.邻苯二甲酸二异辛酯喂养大鼠对肝脏固醇和角鲨烯生物合成的抑制作用
Lipids. 1976 Oct;11(10):769-73. doi: 10.1007/BF02533053.
8
Specific inhibition of fungal sterol biosynthesis by SF 86-327, a new allylamine antimycotic agent.新型烯丙胺类抗真菌剂SF 86-327对真菌甾醇生物合成的特异性抑制作用。
Antimicrob Agents Chemother. 1985 Feb;27(2):252-6. doi: 10.1128/AAC.27.2.252.
9
The hormonal control of amaranthin synthesis in Amaranthus caudatus seedlings.苋菜幼苗中花旗松素合成的激素调控。
Planta. 1975 Jan;127(3):207-12. doi: 10.1007/BF00380717.
10
Hormonal regulation of cotton ovule and fiber growth: Effects of bromodeoxyuridine, AMO-1618 and p-chlorophenoxyisobutyric acid.棉胚珠和纤维生长的激素调控：溴脱氧尿苷、AMO-1618 和对氯苯氧异丁酸的影响。
Planta. 1978 Jan;141(3):269-72. doi: 10.1007/BF00388342.

引用本文的文献

1
Somatic embryogenesis in cell cultures of Glycine species.体细胞胚胎发生在 Glycine 属细胞培养物中。
Plant Cell Rep. 1983 Aug;2(4):209-12. doi: 10.1007/BF00270106.
2
Paclobutrazol Inhibits Abscisic Acid Biosynthesis in Cercospora rosicola.多效唑抑制梨叶点霉脱落酸的生物合成。
Plant Physiol. 1986 Jan;80(1):122-5. doi: 10.1104/pp.80.1.122.
3
Inhibition of Abscisic Acid Biosynthesis in Cercospora rosicola by Inhibitors of Gibberellin Biosynthesis and Plant Growth Retardants.赤霉素生物合成抑制剂和植物生长延缓剂对玫瑰尾孢菌中脱落酸生物合成的抑制作用
Plant Physiol. 1983 Jan;71(1):15-8. doi: 10.1104/pp.71.1.15.
4
Comparative Effects of Ancymidol and Its Analogs on Growth of Peas and Ent-Kaurene Oxidation in Cell-Free Extracts of Immature Marah macrocarpus Endosperm.Ancymidol 及其类似物对未成熟马哈拉马卡里pus 胚乳细胞无细胞提取物中豌豆生长和 Ent-贝壳杉烯氧化的比较影响。
Plant Physiol. 1982 Mar;69(3):707-11. doi: 10.1104/pp.69.3.707.
5
Inhibition of the Development of Induced Respiration and Cyanide-insensitive Respiration in Potato Tuber Slices by Cerulenin and Dimethylaminoethanol.杆菌肽和二甲氨基乙醇抑制马铃薯切片诱导呼吸和氰化物不敏感呼吸的发展。
Plant Physiol. 1977 Jul;60(1):11-6. doi: 10.1104/pp.60.1.11.
6
Effects of Ancymidol (a Growth Retardant) and Triarimol (a Fungicide) on the Growth, Sterols, and Gibberellins of Phaseolus vulgaris (L.).嘧啶醇（一种生长延缓剂）和三唑醇（一种杀菌剂）对菜豆生长、甾醇和赤霉素的影响
Plant Physiol. 1976 Apr;57(4):640-4. doi: 10.1104/pp.57.4.640.
7
Plant growth retardants as inhibitors of sterol biosynthesis in tobacco seedlings.植物生长延缓剂作为烟草幼苗中甾醇生物合成的抑制剂
Plant Physiol. 1974 Sep;54(3):238-45. doi: 10.1104/pp.54.3.238.
8
Correlations of Growth Rate and De-etiolation with Rate of Ent-Kaurene Biosynthesis in Pea (Pisum sativum L.).豌豆（Pisum sativum L.）中生长速度和去黄化与贝壳杉烯生物合成速度的相关性。
Plant Physiol. 1974 Jan;53(1):5-10. doi: 10.1104/pp.53.1.5.
9
Metabolic Control of Avocado Fruit Growth (Isoprenoid Growth Regulators and the Reaction Catalyzed by 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase).鳄梨果实生长的代谢调控（类异戊二烯生长调节剂与3-羟基-3-甲基戊二酰辅酶A还原酶催化的反应）
Plant Physiol. 1997 Jun;114(2):511-518. doi: 10.1104/pp.114.2.511.
10
Oxygen requirements for formation and activity of the squalene epoxidase in Saccharomyces cerevisiae.酿酒酵母中角鲨烯环氧化酶形成和活性的氧气需求。
J Bacteriol. 1983 Aug;155(2):488-92. doi: 10.1128/jb.155.2.488-492.1983.

本文引用的文献

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The effect of phosphon (2,4-dichlorobenzyltributyl phosphonium chloride) as a house fly sterilant.
Naturwissenschaften. 1965 Jul;52(13):400. doi: 10.1007/BF00621442.
2
An enzymic site of inhibition of gibberellin biosynthesis by Amo 1618 and other plant growth retardants.Amo 1618及其他植物生长延缓剂对赤霉素生物合成的酶促抑制位点。
Plant Physiol. 1965 Sep;40(5):948-52. doi: 10.1104/pp.40.5.948.
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(2-chloroethyl)-trimethylammonium chloride inhibits gametogenesis in locusts.（2-氯乙基）-三甲基氯化铵抑制蝗虫的配子发生。
Nature. 1968 Oct 12;220(5163):189-90. doi: 10.1038/220189a0.
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Sites of action of plant growth retardants on cholesterol biosynthesis by cell-free rat liver preparations.
Aust J Biol Sci. 1970 Dec;23(6):1115-24. doi: 10.1071/bi9701115.
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Differential inhibition of rat liver cholesterol biosynthesis by plant growth retardants.
Nature. 1970 Mar 28;225(5239):1252-3. doi: 10.1038/2251252a0.
6
Biosynthesis of gibberellins. IV. Biosynthesis of cyclic diterpenes from trans-geranylgeranyl pyrophosphate.赤霉素的生物合成。IV. 由反式香叶基香叶基焦磷酸合成环状二萜类化合物。
J Biol Chem. 1969 Jun 25;244(12):3200-9.

2-异丙基-4-二甲基氨基-5-甲基苯基-1-哌啶羧酸甲酯盐酸盐在烟草和大鼠肝制剂中对甾醇生物合成的抑制作用。

Inhibition of Sterol Biosynthesis by 2-Isopropyl-4-dimethylamino-5-methylphenyl-1-piperidine Carboxylate Methyl Chloride in Tobacco and Rat Liver Preparations.

机构信息

Department of Plant Physiology, Waite Agricultural Research Institute, University of Adelaide, Glen Osmond, South Australia.

出版信息

Plant Physiol. 1972 Mar;49(3):417-20. doi: 10.1104/pp.49.3.417.

DOI:10.1104/pp.49.3.417
PMID:16657972
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC365976/
Abstract

2-Isopropyl-4-dimethylamino-5-methylphenyl-1-piperidine carboxylate methyl chloride, 90%, applied to rootless tobacco (Nicotiana tabacum cv. Samson) seedlings inhibits the incorporation of (14)C-mevalonate into sterols. Concomitantly, the retardant causes the accumulation of squalene-2,3-epoxide, an intermediate in sterol biosynthesis. The results with tobacco are identical to those produced by the retardant in cell-free rat liver preparations.

摘要

2-异丙基-4-二甲基氨基-5-甲基苯基-1-哌啶羧酸甲酯盐酸盐，90%，应用于无根烟草（Nicotiana tabacum cv. Samson）幼苗中，抑制（14）C-甲羟戊酸掺入甾醇。同时，该抑制剂导致角鲨烯-2,3-环氧化物的积累，这是甾醇生物合成的中间产物。烟草的结果与细胞游离大鼠肝制剂中抑制剂产生的结果相同。