2-异丙基-4-二甲基氨基-5-甲基苯基-1-哌啶羧酸甲酯盐酸盐在烟草和大鼠肝制剂中对甾醇生物合成的抑制作用。
Inhibition of Sterol Biosynthesis by 2-Isopropyl-4-dimethylamino-5-methylphenyl-1-piperidine Carboxylate Methyl Chloride in Tobacco and Rat Liver Preparations.
机构信息
Department of Plant Physiology, Waite Agricultural Research Institute, University of Adelaide, Glen Osmond, South Australia.
出版信息
Plant Physiol. 1972 Mar;49(3):417-20. doi: 10.1104/pp.49.3.417.
Abstract
2-Isopropyl-4-dimethylamino-5-methylphenyl-1-piperidine carboxylate methyl chloride, 90%, applied to rootless tobacco (Nicotiana tabacum cv. Samson) seedlings inhibits the incorporation of (14)C-mevalonate into sterols. Concomitantly, the retardant causes the accumulation of squalene-2,3-epoxide, an intermediate in sterol biosynthesis. The results with tobacco are identical to those produced by the retardant in cell-free rat liver preparations.
摘要
2-异丙基-4-二甲基氨基-5-甲基苯基-1-哌啶羧酸甲酯盐酸盐，90%，应用于无根烟草（Nicotiana tabacum cv. Samson）幼苗中，抑制（14）C-甲羟戊酸掺入甾醇。同时，该抑制剂导致角鲨烯-2,3-环氧化物的积累，这是甾醇生物合成的中间产物。烟草的结果与细胞游离大鼠肝制剂中抑制剂产生的结果相同。
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