Carp N Z, Saputelli J, Halbherr T C, Mason W S, Jilbert A R
Department of Surgery, American Oncologic Hospital, Philadelphia, PA.
Lab Anim Sci. 1991 Oct;41(5):474-5.
Infection of Pekin ducks with duck hepatitis B virus is a useful model for studying the hepadenoviruses, of which human hepatitis B virus is the prototype. The utility of this model has been limited, however, by the difficulties associated with anesthetizing and obtaining liver biopsies from ducks. We developed a technique using Telazol (13 mg/kg) to anesthetize ducks before surgical biopsy of the liver in ducks infected with duck hepatitis B virus. Eight Pekin ducks infected with duck hepatitis B virus underwent serial biopsies at 4- to 5-week intervals. There was one perioperative death in 34 surgical procedures with no evidence on intra-abdominal sepsis or wound complications. Telazol can be used safely and humanely to anesthetized ducks without the need for general endotracheal anesthesia.
用鸭乙型肝炎病毒感染北京鸭是研究肝腺病毒的一种有用模型，其中人类乙型肝炎病毒是原型。然而，该模型的实用性受到与给鸭麻醉和获取肝活检相关的困难的限制。我们开发了一种技术，使用替来他明（13毫克/千克）在对感染鸭乙型肝炎病毒的鸭进行肝脏手术活检前对其进行麻醉。八只感染鸭乙型肝炎病毒的北京鸭每隔4至5周进行一次连续活检。在34次外科手术中有1例围手术期死亡，没有腹腔内感染或伤口并发症的证据。替来他明可以安全且人道地用于麻醉鸭，无需全身气管内麻醉。
