Varagona G, Ellis L A, Moore D, Penney D, Dusheiko G M
Department of Gastroenterology, University of Genoa, Italy.
Lab Anim. 1991 Jul;25(3):254-7. doi: 10.1258/002367791780808400.
Aylesbury ducks (Anas platyrhynchos) chronically infected with the duck hepatitis B virus provide a useful model for studying hepadna-virus infection, replication and the effects of antiviral therapy. In these studies, it is necessary to have an effective method for obtaining repeat liver specimens for histological and molecular analyses. We have therefore developed a percutaneous liver biopsy technique which has a low rate of complications, can be performed at repeated intervals, and provides sufficient quantities of liver tissue for histological and nucleic acid hybridization analysis.
长期感染鸭乙型肝炎病毒的艾尔斯伯里鸭（绿头鸭）为研究嗜肝DNA病毒感染、复制及抗病毒治疗效果提供了一个有用的模型。在这些研究中，有必要拥有一种有效的方法来获取用于组织学和分子分析的重复肝脏标本。因此，我们开发了一种经皮肝活检技术，该技术并发症发生率低，可反复进行，并且能提供足够数量的肝组织用于组织学和核酸杂交分析。
