Pattyn S R
Institute for Tropical Medicine, Antwerp, Belgium.
Int J Lepr Other Mycobact Dis. 1991 Dec;59(4):613-7.
The anti-Mycobacterium leprae activity of several fluoroquinolones (A-56619, A-56620, ofloxacin, fleroxacin, lomefloxacin, temafloxacin, tosufloxacin, and PD-117596) was studied in the mouse. In a dosage of 150 mg/kg administered daily, A-56619 is active and A-56620 is inactive against M. leprae. Ofloxacin administered daily for 2 weeks at 300 mg/kg is bactericidal. The minimal effective dose of PD-117596, lomefloxacin and temafloxacin is less than 37.5 mg/kg. When administered at 300 mg/kg at monthly intervals temafloxacin, PD-117596, and ofloxacin are bacteriostatic; while fleroxacin and lomefloxacin are bactericidal. Tosufloxacin is less active than the other quinolones included in the present study.
在小鼠中研究了几种氟喹诺酮类药物（A-56619、A-56620、氧氟沙星、氟罗沙星、洛美沙星、替马沙星、妥舒沙星和PD-117596）抗麻风分枝杆菌的活性。以每日150mg/kg的剂量给药时，A-56619对麻风分枝杆菌有活性，而A-56620无活性。氧氟沙星以300mg/kg每日给药2周具有杀菌作用。PD-117596、洛美沙星和替马沙星的最小有效剂量小于37.5mg/kg。替马沙星、PD-117596和氧氟沙星以300mg/kg每月间隔给药时具有抑菌作用；而氟罗沙星和洛美沙星具有杀菌作用。妥舒沙星的活性低于本研究中包括的其他喹诺酮类药物。
