Traore I, Ji B, Lienhardt C, Bobin P, Grosset J
Institut Marchoux, Bamako, Mali.
Int J Lepr Other Mycobact Dis. 1996 Jun;64(2):142-5.
The minimal effective dosages (MEDs) of ofloxacin (OFLO) and sparfloxacin (SPFX) against 10 isolates of Mycobacterium leprae were measured in the mouse foot pad system. The drugs were administered either by gavage or by incorporation into the mouse diet in a range of concentrations. The results demonstrated that the MEDs of OFLO were 4 to 5 times higher than those of SPFX, thus confirming that, on a weight-to-weight basis, the anti-M. leprae activity of SPFX was significantly greater than that of OFLO. The MEDs of OFLO/SPFX measured by gavage were 20 times lower than those measured by incorporating the drug into the mouse diet.
在小鼠足垫系统中测定了氧氟沙星（OFLO）和司帕沙星（SPFX）对10株麻风分枝杆菌的最低有效剂量（MEDs）。将药物以一系列浓度通过灌胃或掺入小鼠饮食的方式给药。结果表明，OFLO的MEDs比SPFX高4至5倍，从而证实，以重量计，SPFX对麻风分枝杆菌的活性明显高于OFLO。通过灌胃测定的OFLO/SPFX的MEDs比将药物掺入小鼠饮食中测定的MEDs低20倍。
