Adhikary G, Nandy P, Chandra S, Sikdar R, Sen P C
Department of Chemistry, Bose Institute, Calcutta, India.
Biochem Int. 1991 Dec;25(5):951-61.
Chlorpromazine, an antipsychotic drug is found to inhibit Na+K(+)-ATPase, Ca(2+)-ATPase and acetylcholinesterase activities in the microsomal membranes of rat in vivo, when the drug is injected for certain periods of time. The inhibition seems to be due to the changes in fatty acid composition of lipid and microviscosity of the membranes. However, once the drug has been withdrawn, the enzyme activities are found to return to the normal level in three to five weeks, suggesting that the drug effect is reversible.
抗精神病药物氯丙嗪在大鼠体内注射一定时间后，被发现会抑制大鼠微粒体膜中的钠钾 - ATP酶、钙 - ATP酶和乙酰胆碱酯酶的活性。这种抑制作用似乎是由于膜脂质脂肪酸组成和微粘度的变化所致。然而，一旦停药，酶活性在三到五周内会恢复到正常水平，这表明药物作用是可逆的。
