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[出生后个体发育中小鼠交感干星状神经节神经元的免疫细胞化学特征]

[Immunocytochemical characteristic of neurons of the mouse truncus sympaticus stellate ganglion in postnatal ontogenesis].

作者信息

Masliukov P M, Shilkin V V, Timmermans J P

出版信息

Morfologiia. 2005;128(5):41-4.

PMID:16669243
Abstract

Neurotransmitter content in stellate ganglion neurons was studied immunocytochemically in mice of different ages (newborns, 10-, 20-, 30- and 60-days-old). Majority of the stellate ganglion neurons in mice of all the groups studied were tyrosine hydroxylase (TH)-positive. Most of neurons with the immunore-activity to choline acetyltransferase (ChAT) were shown to be also TH-positive in the newborn and 10-day-old animals. The percentage of neurons containing TH and neuropeptide Y increased from birth throughout all the age periods studied. The proportion of vasoactive intestinal peptide (VIP)- and ChAT-positive neurons was maximal in 10-day-old animals and then decreased up to 60 days of age. The somatostatin- and galanin-reactive cells were absent in all the mice. Thus, the maturation of neurotransmitter composition is complete in the mouse stellate ganglion by the end of the second month of life.

摘要

采用免疫细胞化学方法研究了不同年龄(新生、10日龄、20日龄、30日龄和60日龄)小鼠星状神经节神经元中的神经递质含量。在所研究的所有组别的小鼠中,大多数星状神经节神经元为酪氨酸羟化酶(TH)阳性。在新生和10日龄动物中,大多数对胆碱乙酰转移酶(ChAT)具有免疫活性的神经元也为TH阳性。在整个研究的年龄阶段,含TH和神经肽Y的神经元百分比从出生起就不断增加。血管活性肠肽(VIP)和ChAT阳性神经元的比例在10日龄动物中最高,然后在60日龄时下降。所有小鼠中均未发现生长抑素和甘丙肽反应性细胞。因此,在出生后第二个月末,小鼠星状神经节中神经递质组成的成熟已完成。

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