一种由亚胺和酰氯直接一步合成咪唑的方法：钯催化多组分偶联法。
A direct, one step synthesis of imidazoles from imines and acid chlorides: a palladium catalyzed multicomponent coupling approach.
作者信息
Siamaki Ali R, Arndtsen Bruce A
机构信息
Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 2K6, Canada.
出版信息
J Am Chem Soc. 2006 May 10;128(18):6050-1. doi: 10.1021/ja060705m.
A palladium-catalyzed one-step synthesis of imidazoles from imines and acid chlorides is described. A plausible mechanism for this multicomponent reaction is provided, which explains the selective incorporation of two different imines into the final product with perfect regiocontrol. Overall, this catalytic process provides a modular method to prepare imidazoles directly from building blocks that are all either commercially available or readily generated.
描述了一种钯催化的由亚胺和酰氯一步合成咪唑的方法。提供了该多组分反应的一种合理机制，该机制解释了两种不同亚胺以完美的区域控制选择性地并入最终产物的过程。总体而言，这种催化过程提供了一种模块化方法，可直接从市售或易于制备的起始原料制备咪唑。
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