钯催化的炔烃、亚胺和酰氯的多组分偶联反应：一种直接且模块化的吡咯合成方法。
Palladium-catalyzed multicomponent coupling of alkynes, imines, and acid chlorides: a direct and modular approach to pyrrole synthesis.
作者信息
Dhawan Rajiv, Arndtsen Bruce A
机构信息
Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 2K6, Canada.
出版信息
J Am Chem Soc. 2004 Jan 21;126(2):468-9. doi: 10.1021/ja039152v.
A new palladium-catalyzed method to prepare pyrroles directly from three basic building blocks-imines, alkynes, and acid chlorides-is described. This approach provides a straightforward method both to prepare pyrroles in one step and to diversify their structure by simple variation of any of the three starting materials. Mechanistic studies suggest that this process occurs via a complex series of eight individual steps, and this is discussed.
描述了一种新的钯催化方法，可直接由三种基本结构单元——亚胺、炔烃和酰氯制备吡咯。这种方法提供了一种直接的方法，既能一步制备吡咯，又能通过简单改变三种起始原料中的任何一种来使其结构多样化。机理研究表明，该过程通过一系列复杂的八个独立步骤发生，并对此进行了讨论。
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