De Villard R, Flachaire E, Laujin A, Maillet J, Revol O, Charles S, Mamelle J C, Renaud B, Quincy C
Service de psychopathologie de l'enfant et de l'adolescent, hôpital neurologique, Lyon, France.
Pediatrie. 1991;46(12):813-6.
High platelet serotonin concentrations have been reported in children with early infantile autism. However, as yet there are no reference values regarding platelet serotonin in normal infants and young children so that it remains difficult to define the exact significance of this finding. We report here with the platelet serotonin concentration found in 57 infants and children (20 girls, 37 boys) ranging in age from 10 days to 5 years old. Our results show that mean platelet serotonin concentrations in infants and young children are significantly greater than mean values obtained in older children (+11%) and neonates in the umbilical cord (+64%). No significant variations were found relating to sex, leucocyte count and platelet count. There therefore appears to be a physiological elevation of platelet serotonin concentration in infants and young children, and this has to be taken into consideration in the interpretation of the elevated values found in cases of infantile autism.
据报道，患有早期婴儿自闭症的儿童血小板血清素浓度较高。然而，目前尚无正常婴幼儿血小板血清素的参考值，因此难以确定这一发现的确切意义。我们在此报告了57名年龄在10天至5岁之间的婴幼儿（20名女孩，37名男孩）的血小板血清素浓度。我们的结果表明，婴幼儿的平均血小板血清素浓度显著高于大龄儿童（高11%）和新生儿脐带血（高64%）的平均值。未发现与性别、白细胞计数和血小板计数相关的显著差异。因此，婴幼儿的血小板血清素浓度似乎存在生理性升高，在解释婴儿自闭症病例中发现的升高值时必须考虑到这一点。
